Variation of Glycosylated Hemoglobin (HbA1C) Cutoff among type-2 diabetic nephropathy Patients

Objectives: The aim of the study was to determine glycosylated hemogobin (HbA1c) cut-off and lipid correlation, duration of diabetes with level of proteinuria. Materials And Methods: Cross sectional study was done on 250 patients with type-2 diabetes mellitus subjects attending medicine clinic , King george’s medical university (KGMU) lucknow, india. Subjects were screened for diabetic nephropathy depending on the base line parameter, clinical history of disease and documented in pretested proforma. Routine blood parameters, HbA1C and 24 hrs urine microalbumin level were carried out in department of pathology. Result: The level of HbA1c was higher among the patients of nephropathy (8.54±0.97) compared with non-nephropathy (7.32±0.84, 95%CI=7.17-7.47). Increased HbA1c was found among both 5-10 and >10 years diabetic duration . However, HbA1c was similar among all duration of diabetes groups within non-nephropathy. The total cholesterol (TC), HDL cholesterol (HDL-c), LDL cholesterol (LDL-c) and VLDL cholesterol (VLDL-C) were almost similar in HbA1c range <7, 7-8.9 and 9-10.9 and without insignificant differences (p>0.05). Although, Triglyceride (TG) level was significantly higher in HbA1c 9-10.9 (174.20±48.95mg%) than 7-8.9 (159.66±31.47mg%) and <7 (158.82±29.67mg%) . High prevalence of nephropathy was found among HbA1c range 9-10.9 (Urine albumin :246.35±126.29mg/d) compared with 7-8.99 (Urine albumin :159.89±70.16mg/d) and <7 (Urine albumin :132.80±90.33mg/d) respectively. Conclusion : HbA1c cut-off >7 % should be considered as an index of glycemic control as well as important tool for over all metabolic derangement and target organ damage among diabetes population. Hence, establishment of HbA1c cut-off value with long duration of diabetes might be useful for prediction of treatment control and prevention of renal failure. Keywords; Diabetic Nephropathy; Glycosylated Hemoglobin; Triglyceride; Renal failure Received: August 28,2018; Accepted: September 19,2018; Published: October 26,2018 *Corresponding author : Mohammed Idrees Khan , Assistant Professor, Department of Clinical Nutrition, College of Applied Health Sciences in Arras, Qassim University (K.S.A),Tel: +966-537234624,E-mail: mohdidreesh06@gmail.com