自由基对精子DNA的影响及抗氧化保护作用;评估和审查

S. Pourmasumi, P. Sabeti
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引用次数: 1

摘要

氧化应激是ROS和抗氧化剂水平之间的失衡。精子膜富含多不饱和脂肪酸,对自由基的增加非常敏感。ROS水平的增加会导致精子膜脂质过氧化增加,其柔韧性降低,最终导致精子活力下降。此外,氧化应激可能损害精子的轴索和线粒体功能,以及DNA完整性、RNA和蛋白质合成。多项研究表明,抗氧化剂对人体健康有益,可用于预防癌症和冠状动脉疾病。基于目前的综述,关于抗氧化剂对精子细胞的保护作用有更多的文献。研究表明,在精子样本中添加体外抗氧化剂可以提高精子活力、形态等参数,减少精子膜脂质过氧化和DNA损伤。此外,体内或口服抗氧化剂补充对精子具有保护作用,使其免受ROS的负面影响。由于不孕的原因多种多样,缺乏抗氧化剂来减少精子DNA损伤,抗氧化活性的水平取决于摄入的类型、剂量和持续时间,因此需要更多的研究来确定合适的抗氧化剂类型、体内和体外给药的剂量和时间。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The effect of free radicals on sperm DNA and antioxidant protective role; an assessment and review
Oxidative stress is an imbalance between the level of ROS and antioxidants. Sperm membranes are rich in polyunsaturated fatty acids and are very sensitive to increased free radicals. Increasing the level of ROS can lead to an increase in lipid peroxidation in sperm membrane, decrease in their flexibility, and ultimately a decrease in sperm motility. Also, oxidative stress may impair sperm axonemal and mitochondrial function, as well as DNA integrity, RNA and protein synthesis. Several studies have shown that antioxidants are beneficial to human health and are used to prevent cancer and coronary artery disease. Based on the present review, there are more documents in protective effects of antioxidants on sperm cells. Studies showed adding in vitro antioxidants to sperm samples can increase sperm parameters such as sperm motility, morphology and decrease sperm membrane lipid peroxidation and sperm DNA damage. Also in vivo or oral antioxidants supplementation has protective effects on sperm from ROS negative effects. Since the causes of infertility are various, the lack of antioxidants action in reducing the sperm DNA damage, the level of antioxidant activity depends on the type, dose and duration of intake, so more studies are needed to determine the appropriate antioxidant type, the dosage and timing of administration in vivo and in vitro.
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