高强度间歇训练与低强度连续训练对C57BL/6小鼠髓磷脂合成相关基因的影响

M. Naghibzadeh, R. Ranjbar, M. Tabandeh, A. Habibi, Z. Ghotbeddin
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引用次数: 0

摘要

摘要导读:通过增加对髓鞘形成的科学关注,确定影响髓鞘形成的因素是脑健康的重要目标。有一些研究表明,经常锻炼可以改善髓鞘和神经元再生。然而,运动强度对髓鞘形成的影响尚不清楚。因此,本研究的目的是比较高强度间歇训练(HIIT)与低强度连续训练(LICT)对C57BL/6小鼠海马髓磷脂合成相关基因的影响。材料与方法:雄性C57BL/6小鼠30只,随机分为3组:对照组(C)、间歇训练组(IT)和连续训练组(CT)。在跑步机上训练8周后,分析海马髓鞘碱性蛋白(MBP)和蛋白脂质蛋白(PLP)基因的表达。数据分析采用方差分析。结果:与LICT组和对照组相比,HIIT方案显著提高了MBP和PLP mRNA水平(P < 0.05)。结论:我们的研究结果表明,HIIT比LICT更有效地改善了海马中MBP和PLP基因的表达。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Comparison of high-intensity interval versus low-intensity continuous training for myelin synthesis related genes in C57BL/6 mice
Abstract Introduction: By increasing the scientific focus on myelination, identifying factors that influence the myelination is an important goal for brain health. There are some studies that regular exercise improves myelin sheath and neuronal regeneration. However, the effects of exercise intensities on the myelination remain unclear. Therefore, the purpose of this study was to compare the effect of high-intensity interval (HIIT) versus low-intensity continuous training (LICT) on myelin synthesis-related genes in hippocampus of C57BL/6 mice. Materials and methods: Male C57BL/6 mice (n = 30) were randomly assigned to 3 groups: control (C), Interval training (IT), and Continuous training (CT). Training programs on the treadmill were performed for 8 weeks and then, the hippocampus of animals was analyzed for the expression of myelin basic protein (MBP) and proteolipid protein (PLP) genes. Data were analyzed using ANOVA. Results: The result showed that HIIT program significantly increased the mRNA levels of MBP and PLP in comparison with LICT and Control groups (P 0.05). Conclusion: Our results showed that HIIT had a more efficient by improving the expression of MBP and PLP genes compared to LICT in the hippocampus.
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