棒状和圆形纳米羟基磷灰石对洋葱根干细胞的影响

IF 1 Q3 MULTIDISCIPLINARY SCIENCES
Merve Güneş, B. Yalçın, Ayşen Yağmur Kurşun, Ghada Tagorti, Emre Yavuz, E. Akarsu, N. Kaya, Bülent Kaya
{"title":"棒状和圆形纳米羟基磷灰石对洋葱根干细胞的影响","authors":"Merve Güneş, B. Yalçın, Ayşen Yağmur Kurşun, Ghada Tagorti, Emre Yavuz, E. Akarsu, N. Kaya, Bülent Kaya","doi":"10.35378/gujs.1218829","DOIUrl":null,"url":null,"abstract":"Biomaterials are engineering products that are widely used in many medical fields such as orthopaedic applications, facial and maxillofacial surgery, artificial heart parts, metal parts and implantable devices. These materials are widely used in medicine because they are compatible with the organism, are not allergic, and are resistant to physical and chemical factors. Hydroxyapatites are bioactive calcium phosphate ceramics that are compatible with tissues. To increase their bioactivity, nano-sized hydroxyapatite has been produced. Although there are advantages to the use of nanoparticles in the medical field, the potentially toxic effects of these materials on the environment and human health are of concern. It is also one of the topics to be investigated whether the different forms of the same nanoparticle will cause differences in genotoxicity. In this study, the potential genotoxic effects of rod and round forms of nano-sized hydroxyapatites (nHAs) were evaluated in Allium cepa Single Cell Gel Electrophoresis (COMET) method. According to the results, the round form of nHA in the A. cepa meristem root tip cells caused statistically significant genotoxicity at 25 ppm concentration in terms of tail density and tail moment. This study showed small-sized-nanohydroxyapatite-induced genotoxicity and cell death in A. cepa. This study has shown that the physical properties of nanoparticles affect potential toxicity mechanisms.","PeriodicalId":12615,"journal":{"name":"gazi university journal of science","volume":null,"pages":null},"PeriodicalIF":1.0000,"publicationDate":"2023-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The Effects of Rod and Round-Like Nanohydroxyapatites on Allium cepa Root Meristem Cells\",\"authors\":\"Merve Güneş, B. Yalçın, Ayşen Yağmur Kurşun, Ghada Tagorti, Emre Yavuz, E. Akarsu, N. Kaya, Bülent Kaya\",\"doi\":\"10.35378/gujs.1218829\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Biomaterials are engineering products that are widely used in many medical fields such as orthopaedic applications, facial and maxillofacial surgery, artificial heart parts, metal parts and implantable devices. These materials are widely used in medicine because they are compatible with the organism, are not allergic, and are resistant to physical and chemical factors. Hydroxyapatites are bioactive calcium phosphate ceramics that are compatible with tissues. To increase their bioactivity, nano-sized hydroxyapatite has been produced. Although there are advantages to the use of nanoparticles in the medical field, the potentially toxic effects of these materials on the environment and human health are of concern. It is also one of the topics to be investigated whether the different forms of the same nanoparticle will cause differences in genotoxicity. In this study, the potential genotoxic effects of rod and round forms of nano-sized hydroxyapatites (nHAs) were evaluated in Allium cepa Single Cell Gel Electrophoresis (COMET) method. According to the results, the round form of nHA in the A. cepa meristem root tip cells caused statistically significant genotoxicity at 25 ppm concentration in terms of tail density and tail moment. This study showed small-sized-nanohydroxyapatite-induced genotoxicity and cell death in A. cepa. This study has shown that the physical properties of nanoparticles affect potential toxicity mechanisms.\",\"PeriodicalId\":12615,\"journal\":{\"name\":\"gazi university journal of science\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.0000,\"publicationDate\":\"2023-04-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"gazi university journal of science\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.35378/gujs.1218829\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"MULTIDISCIPLINARY SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"gazi university journal of science","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.35378/gujs.1218829","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MULTIDISCIPLINARY SCIENCES","Score":null,"Total":0}
引用次数: 0

摘要

生物材料是一种工程产品,广泛应用于许多医疗领域,如整形外科、面部和颌面外科、人工心脏部件、金属部件和植入式设备。这些材料被广泛用于医学,因为它们与生物体相容,不过敏,并且对物理和化学因素具有抵抗力。羟基磷灰石是一种与组织相容的具有生物活性的磷酸钙陶瓷。为了提高它们的生物活性,已经制备了纳米羟基磷灰石。尽管在医学领域使用纳米颗粒有好处,但这些材料对环境和人类健康的潜在毒性影响令人担忧。同一纳米颗粒的不同形式是否会导致遗传毒性的差异也是有待研究的主题之一。在本研究中,用洋葱单细胞凝胶电泳(COMET)方法评估了棒状和圆形纳米羟基磷灰石(nHAs)的潜在遗传毒性作用。根据结果,洋葱分生组织根尖细胞中圆形的nHA在25ppm浓度下就尾部密度和尾部力矩而言引起统计学上显著的遗传毒性。本研究表明,小尺寸纳米羟基磷灰石诱导洋葱的遗传毒性和细胞死亡。这项研究表明,纳米颗粒的物理性质影响潜在的毒性机制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Effects of Rod and Round-Like Nanohydroxyapatites on Allium cepa Root Meristem Cells
Biomaterials are engineering products that are widely used in many medical fields such as orthopaedic applications, facial and maxillofacial surgery, artificial heart parts, metal parts and implantable devices. These materials are widely used in medicine because they are compatible with the organism, are not allergic, and are resistant to physical and chemical factors. Hydroxyapatites are bioactive calcium phosphate ceramics that are compatible with tissues. To increase their bioactivity, nano-sized hydroxyapatite has been produced. Although there are advantages to the use of nanoparticles in the medical field, the potentially toxic effects of these materials on the environment and human health are of concern. It is also one of the topics to be investigated whether the different forms of the same nanoparticle will cause differences in genotoxicity. In this study, the potential genotoxic effects of rod and round forms of nano-sized hydroxyapatites (nHAs) were evaluated in Allium cepa Single Cell Gel Electrophoresis (COMET) method. According to the results, the round form of nHA in the A. cepa meristem root tip cells caused statistically significant genotoxicity at 25 ppm concentration in terms of tail density and tail moment. This study showed small-sized-nanohydroxyapatite-induced genotoxicity and cell death in A. cepa. This study has shown that the physical properties of nanoparticles affect potential toxicity mechanisms.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
gazi university journal of science
gazi university journal of science MULTIDISCIPLINARY SCIENCES-
CiteScore
1.60
自引率
11.10%
发文量
87
期刊介绍: The scope of the “Gazi University Journal of Science” comprises such as original research on all aspects of basic science, engineering and technology. Original research results, scientific reviews and short communication notes in various fields of science and technology are considered for publication. The publication language of the journal is English. Manuscripts previously published in another journal are not accepted. Manuscripts with a suitable balance of practice and theory are preferred. A review article is expected to give in-depth information and satisfying evaluation of a specific scientific or technologic subject, supported with an extensive list of sources. Short communication notes prepared by researchers who would like to share the first outcomes of their on-going, original research work are welcome.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信