Merve Güneş, B. Yalçın, Ayşen Yağmur Kurşun, Ghada Tagorti, Emre Yavuz, E. Akarsu, N. Kaya, Bülent Kaya
{"title":"棒状和圆形纳米羟基磷灰石对洋葱根干细胞的影响","authors":"Merve Güneş, B. Yalçın, Ayşen Yağmur Kurşun, Ghada Tagorti, Emre Yavuz, E. Akarsu, N. Kaya, Bülent Kaya","doi":"10.35378/gujs.1218829","DOIUrl":null,"url":null,"abstract":"Biomaterials are engineering products that are widely used in many medical fields such as orthopaedic applications, facial and maxillofacial surgery, artificial heart parts, metal parts and implantable devices. These materials are widely used in medicine because they are compatible with the organism, are not allergic, and are resistant to physical and chemical factors. Hydroxyapatites are bioactive calcium phosphate ceramics that are compatible with tissues. To increase their bioactivity, nano-sized hydroxyapatite has been produced. Although there are advantages to the use of nanoparticles in the medical field, the potentially toxic effects of these materials on the environment and human health are of concern. It is also one of the topics to be investigated whether the different forms of the same nanoparticle will cause differences in genotoxicity. In this study, the potential genotoxic effects of rod and round forms of nano-sized hydroxyapatites (nHAs) were evaluated in Allium cepa Single Cell Gel Electrophoresis (COMET) method. According to the results, the round form of nHA in the A. cepa meristem root tip cells caused statistically significant genotoxicity at 25 ppm concentration in terms of tail density and tail moment. This study showed small-sized-nanohydroxyapatite-induced genotoxicity and cell death in A. cepa. This study has shown that the physical properties of nanoparticles affect potential toxicity mechanisms.","PeriodicalId":12615,"journal":{"name":"gazi university journal of science","volume":" ","pages":""},"PeriodicalIF":1.0000,"publicationDate":"2023-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The Effects of Rod and Round-Like Nanohydroxyapatites on Allium cepa Root Meristem Cells\",\"authors\":\"Merve Güneş, B. Yalçın, Ayşen Yağmur Kurşun, Ghada Tagorti, Emre Yavuz, E. Akarsu, N. Kaya, Bülent Kaya\",\"doi\":\"10.35378/gujs.1218829\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Biomaterials are engineering products that are widely used in many medical fields such as orthopaedic applications, facial and maxillofacial surgery, artificial heart parts, metal parts and implantable devices. These materials are widely used in medicine because they are compatible with the organism, are not allergic, and are resistant to physical and chemical factors. Hydroxyapatites are bioactive calcium phosphate ceramics that are compatible with tissues. To increase their bioactivity, nano-sized hydroxyapatite has been produced. Although there are advantages to the use of nanoparticles in the medical field, the potentially toxic effects of these materials on the environment and human health are of concern. It is also one of the topics to be investigated whether the different forms of the same nanoparticle will cause differences in genotoxicity. In this study, the potential genotoxic effects of rod and round forms of nano-sized hydroxyapatites (nHAs) were evaluated in Allium cepa Single Cell Gel Electrophoresis (COMET) method. According to the results, the round form of nHA in the A. cepa meristem root tip cells caused statistically significant genotoxicity at 25 ppm concentration in terms of tail density and tail moment. This study showed small-sized-nanohydroxyapatite-induced genotoxicity and cell death in A. cepa. This study has shown that the physical properties of nanoparticles affect potential toxicity mechanisms.\",\"PeriodicalId\":12615,\"journal\":{\"name\":\"gazi university journal of science\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":1.0000,\"publicationDate\":\"2023-04-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"gazi university journal of science\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.35378/gujs.1218829\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"MULTIDISCIPLINARY SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"gazi university journal of science","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.35378/gujs.1218829","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MULTIDISCIPLINARY SCIENCES","Score":null,"Total":0}
The Effects of Rod and Round-Like Nanohydroxyapatites on Allium cepa Root Meristem Cells
Biomaterials are engineering products that are widely used in many medical fields such as orthopaedic applications, facial and maxillofacial surgery, artificial heart parts, metal parts and implantable devices. These materials are widely used in medicine because they are compatible with the organism, are not allergic, and are resistant to physical and chemical factors. Hydroxyapatites are bioactive calcium phosphate ceramics that are compatible with tissues. To increase their bioactivity, nano-sized hydroxyapatite has been produced. Although there are advantages to the use of nanoparticles in the medical field, the potentially toxic effects of these materials on the environment and human health are of concern. It is also one of the topics to be investigated whether the different forms of the same nanoparticle will cause differences in genotoxicity. In this study, the potential genotoxic effects of rod and round forms of nano-sized hydroxyapatites (nHAs) were evaluated in Allium cepa Single Cell Gel Electrophoresis (COMET) method. According to the results, the round form of nHA in the A. cepa meristem root tip cells caused statistically significant genotoxicity at 25 ppm concentration in terms of tail density and tail moment. This study showed small-sized-nanohydroxyapatite-induced genotoxicity and cell death in A. cepa. This study has shown that the physical properties of nanoparticles affect potential toxicity mechanisms.
期刊介绍:
The scope of the “Gazi University Journal of Science” comprises such as original research on all aspects of basic science, engineering and technology. Original research results, scientific reviews and short communication notes in various fields of science and technology are considered for publication. The publication language of the journal is English. Manuscripts previously published in another journal are not accepted. Manuscripts with a suitable balance of practice and theory are preferred. A review article is expected to give in-depth information and satisfying evaluation of a specific scientific or technologic subject, supported with an extensive list of sources. Short communication notes prepared by researchers who would like to share the first outcomes of their on-going, original research work are welcome.