B细胞介导的抗结核感染免疫:一项小型综述研究

M. Karbalaei, S. Soleimanpour, M. Eslami, B. Yousefi, M. Keikha
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引用次数: 1

摘要

结核分枝杆菌(Mtb)被认为是一个主要的公共卫生问题,也是一种成功的细胞内病原体,在世界范围内与高死亡率相关。卡介苗是唯一可用于预防儿童结核病和结核性脑膜炎的疫苗。然而,BCG在治疗成人结核病方面并不充分有效。根据文献,关于B细胞的潜在作用,有争议的数据。B细胞和体液免疫反应在宿主对TB免疫反应的扩增中起着关键作用。本综述旨在探讨结核感染中的B细胞和体液免疫反应,并评估其作为治疗选择的应用。监测结核病中的各种B细胞表型可能是预测个体结核病的可靠标志物,尤其是潜伏型结核病。根据研究结果,CMI反应(尤其是Th1活性)不足以有效预防结核病,B细胞和Abs影响先天免疫细胞和Th1,同时在接触结核杆菌的各种结果中起着关键作用。尽管B细胞可能在活动性结核病的发展中参与Mtb,但还需要进一步研究B细胞和体液免疫对结核病发病机制和靶向有害体液介导反应的影响。此外,B细胞和抗体可能是合适的生物标志物,以促进有关检测潜伏性结核病再激活的可靠诊断工具的研究,并用作新一代的治疗选择。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
B cell-mediated Immunity against Tuberculosis Infection: A Mini Review Study
Mycobacterium tuberculosis (Mtb) is considered to be a major public health concern and a successful intracellular pathogen associated with high mortality worldwide. The Bacillus Calmette-Guerin (BCG) vaccine is the only available vaccine for the prevention of tuberculosis (TB) and tubercular meningitis in children. However, BCG is not adequately effective in the treatment of the adults affected to TB. According to the literature, there are controversial data on the potential role of B cells. B cells and humoral immune response play a key role in the amplification of the host immune response against TB. This review study aimed to discuss B cells and humoral immune responses in TB infection and assess its application as a therapeutic option. The monitoring of various B cell phenotypes in TB could be a reliable marker for the prediction of TB in individuals, especially in the latent form. According to the findings, the CMI response (especially Th1 activities) is not sufficient for efficient protection against TB, and B cells and Abs influence the innate immunocytes and Th1, while playing a pivotal role in various outcomes of exposure with tubercle bacilli. Although B cells may contribute to Mtb in the development of active TB, further investigations are required regarding the effects of B cells and humoral immunity on TB pathogenesis and the targeted harmful humoral-mediated response. Moreover, B cells and antibodies could be proper biomarkers to promote the studies regarding the detection of reliable diagnostic tools for the reactivation of latent TB, as well as use as a new generation of therapeutic options.
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