磷酸胺接枝纤维素固定化钯纳米粒子用于尿嘧啶芳基化反应

IF 0.9 Q4 CHEMISTRY, PHYSICAL

Current Organocatalysis Pub Date : 2021-08-16 DOI:10.2174/2213337208666210816110719

Qian Yang, Na Ma, Yangqing He, Xiaojiao Yu, B. Yao

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引用次数: 0

摘要

5-芳基化尿嘧啶核苷的合成是一个迫切的挑战。特别是以N-无保护的尿嘧啶为原料的suzuki反应方法，具有提高产率的潜力。为了找到一种更有效的催化剂来提高芳基脲和芳基脲的产率。我们首先以纤维素为原料构建了光气胺接枝纤维素（PAGC）。然后通过加热和还原PAGC和Pa（OAc）2的混合物制备了纳米催化剂PAGC/Pd（0）。当使用这种纳米催化剂催化5-碘尿嘧啶或5-碘尿苷与芳基杂环硼酸的Suzuki反应时。芳基化产率已经显著提高。这意味着所得纳米催化剂对5-碘尿嘧啶和5-碘尿苷的Suzuki芳基化表现出显著的催化效果。

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Immobilized Palladium nanoparticles on phosphanamine-grafted cellulose for arylation of uracil

The synthesis of 5-arylation uracil nucleosides is an imperative challenge. Especially for the method of suzuki reaction using N-unprotected uracil as materials, which holds potential to enhance the yield. In order to find a more efficient catalyst to increase the yield of aryluracils and aryluridines. We first constructed the phosphanamine-grafted cellulose (PAGC) from cellulose material. And then prepared the nanocatalyst PAGC/Pd(0) through heating and reducing the mixture of PAGC and Pa(OAc)2. When using this nanocatalyst to catalyze the Suzuki reaction of 5-iodouracil or 5-iodouridine and aryl heterocyclic boronic acids. The arylation yields have been a significantly improvement. This means that the resultant nanocatalyst exhibits a remarkable catalytic efficacy for Suzuki arylation of 5-iodouracil and 5-iodouridine.

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来源期刊

Current Organocatalysis CHEMISTRY, PHYSICAL-

CiteScore

2.00

自引率

0.00%

发文量

期刊介绍： Current Organocatalysis is an international peer-reviewed journal that publishes significant research in all areas of organocatalysis. The journal covers organo homogeneous/heterogeneous catalysis, innovative mechanistic studies and kinetics of organocatalytic processes focusing on practical, theoretical and computational aspects. It also includes potential applications of organocatalysts in the fields of drug discovery, synthesis of novel molecules, synthetic method development, green chemistry and chemoenzymatic reactions. This journal also accepts papers on methods, reagents, and mechanism of a synthetic process and technology pertaining to chemistry. Moreover, this journal features full-length/mini review articles within organocatalysis and synthetic chemistry. It is the premier source of organocatalysis and synthetic methods related information for chemists, biologists and engineers pursuing research in industry and academia.