立体异构化过程的药学意义

Pub Date : 2023-01-16 DOI:10.15255/kui.2022.027

Lucija Hok, Davorin Šakić, Valerije Vrček, Robert Vianello

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引用次数: 0

摘要

立体异构过程的研究在药物化学和生物医学中具有极其重要的意义。不同的异构体在与生物大分子相互作用时会表现出显著的差异，这可能导致其药代动力学和药理学特性的改变，从而表现出不同的治疗和不良效果。尽管有许多例子说明了立体化学的重要性，但本文概述了药学中最重要和最具代表性的案例。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Farmaceutski značaj procesa stereoizomerizacije

Investigation of the stereoisomerisation process is of the utmost importance in pharmaceutical chemistry and biomedicine. Different isomers can exhibit significant differences when interacting with biological macromolecules, which may result in their modified pharmacokinetic and phar - macodynamic properties, thereby showing different therapeutic and undesirable effects. Although there are numerous examples illustrating the importance of stereochemistry, this article presents an overview of the most significant and representative cases in pharmacy.

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