Wnt16的错义变体RS2908004在人类原始成骨细胞中充当FAM3C的eQTL

IF 0.5 Q4 ENDOCRINOLOGY & METABOLISM

Revista de Osteoporosis y Metabolismo Mineral Pub Date : 2021-12-01 DOI:10.4321/s1889-836x2021000400003

N. Martinez-Gil, J. Patiño, N. Ugartondo, D. Grinberg, S. Balcells

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引用次数: 0

摘要

这种变异对骨密度的影响可能是由于FAM3C表达水平的改变，而不是由氨基酸改变引起的WNT16突变蛋白的直接影响。关键词:WNT16，骨密度，骨质疏松，转录。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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La variante missense rs2908004 de WNT16 actúa como eQTL de FAM3C en osteoblastos primarios humanos

de esta variante sobre la DMO sea debido a la modificación de los niveles de expresión de FAM3C además o en vez de un efecto directo de la proteína WNT16 mutante resultante del cambio de aminoácido. Palabras clave: WNT16 , densidad mineral ósea, osteoporosis, transcripción.

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来源期刊

Revista de Osteoporosis y Metabolismo Mineral ENDOCRINOLOGY & METABOLISM-

CiteScore

0.80

自引率

16.70%

发文量

审稿时长

8 weeks

期刊介绍： The Journal of Osteoporosis and Mineral Metabolism (Rev Osteoporos Metab Miner; www.revistadeosteoporosisymetabolismomineral.es) is the official organ of scientific expression of the Spanish Society for Bone Research and Mineral Metabolism (SEIOMM), who owns all rights over it. Its periodicity is quarterly (4 numbers a year, spring, summer, autumn and winter), with a variable number of extraordinary monographs. The third issue of the year, autumn, is intended for the publication of the communications of the annual Congress of the SEIOMM. The Journal of Osteoporosis and Mineral Metabolism (hereinafter ROMM) publishes works in Spanish, which will be translated into English, and is offered free of charge through its website.