M. Camilli, G. Iannaccone, M. D. Del Buono, F. Crea, N. Aspromonte
{"title":"冠状动脉疾病的遗传背景:临床意义和前景","authors":"M. Camilli, G. Iannaccone, M. D. Del Buono, F. Crea, N. Aspromonte","doi":"10.1080/23808993.2020.1746640","DOIUrl":null,"url":null,"abstract":"ABSTRACT Introduction Both genetic background and life-style factors influence coronary artery disease (CAD) individual risk and clinical manifestations. Areas covered Over the last decades, cardiovascular disease (CVD) emerged as the most important cause of morbidity and mortality worldwide, leading the scientific community to nourish increased interest in cardiovascular risk factors control. Several cohort studies have shown that a family history of ischemic heart disease is common among patients suffering from CAD, suggesting that genetic factors play a role of utmost relevance. The techniques used to study the genetic basis of these diseases have evolved from linkage studies to candidate gene studies and genome-wide association studies (GWAS). Linkage studies have been able to identify genetic variants associated with monogenic diseases, whereas genome-wide association studies have been more successful in determining genetic variants associated with complex diseases. However, family context transmits not only genetic information, but also attitudes and lifestyle habits which proved to significantly influence the overall cardiovascular risk. Expert opinion In the era of patient-tailored management, the aim of this review is to summarize the genetic background of patients with CAD, focusing on the most updated gene-targeted therapies, providing potential future perspectives of pharmacogenetics utility in daily clinical practice.","PeriodicalId":12124,"journal":{"name":"Expert Review of Precision Medicine and Drug Development","volume":null,"pages":null},"PeriodicalIF":1.0000,"publicationDate":"2020-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/23808993.2020.1746640","citationCount":"0","resultStr":"{\"title\":\"Genetic background of coronary artery disease: clinical implications and perspectives\",\"authors\":\"M. Camilli, G. Iannaccone, M. D. Del Buono, F. Crea, N. 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Linkage studies have been able to identify genetic variants associated with monogenic diseases, whereas genome-wide association studies have been more successful in determining genetic variants associated with complex diseases. However, family context transmits not only genetic information, but also attitudes and lifestyle habits which proved to significantly influence the overall cardiovascular risk. Expert opinion In the era of patient-tailored management, the aim of this review is to summarize the genetic background of patients with CAD, focusing on the most updated gene-targeted therapies, providing potential future perspectives of pharmacogenetics utility in daily clinical practice.\",\"PeriodicalId\":12124,\"journal\":{\"name\":\"Expert Review of Precision Medicine and Drug Development\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.0000,\"publicationDate\":\"2020-04-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1080/23808993.2020.1746640\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Expert Review of Precision Medicine and Drug Development\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1080/23808993.2020.1746640\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"PHARMACOLOGY & PHARMACY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Expert Review of Precision Medicine and Drug Development","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1080/23808993.2020.1746640","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
Genetic background of coronary artery disease: clinical implications and perspectives
ABSTRACT Introduction Both genetic background and life-style factors influence coronary artery disease (CAD) individual risk and clinical manifestations. Areas covered Over the last decades, cardiovascular disease (CVD) emerged as the most important cause of morbidity and mortality worldwide, leading the scientific community to nourish increased interest in cardiovascular risk factors control. Several cohort studies have shown that a family history of ischemic heart disease is common among patients suffering from CAD, suggesting that genetic factors play a role of utmost relevance. The techniques used to study the genetic basis of these diseases have evolved from linkage studies to candidate gene studies and genome-wide association studies (GWAS). Linkage studies have been able to identify genetic variants associated with monogenic diseases, whereas genome-wide association studies have been more successful in determining genetic variants associated with complex diseases. However, family context transmits not only genetic information, but also attitudes and lifestyle habits which proved to significantly influence the overall cardiovascular risk. Expert opinion In the era of patient-tailored management, the aim of this review is to summarize the genetic background of patients with CAD, focusing on the most updated gene-targeted therapies, providing potential future perspectives of pharmacogenetics utility in daily clinical practice.
期刊介绍:
Expert Review of Precision Medicine and Drug Development publishes primarily review articles covering the development and clinical application of medicine to be used in a personalized therapy setting; in addition, the journal also publishes original research and commentary-style articles. In an era where medicine is recognizing that a one-size-fits-all approach is not always appropriate, it has become necessary to identify patients responsive to treatments and treat patient populations using a tailored approach. Areas covered include: Development and application of drugs targeted to specific genotypes and populations, as well as advanced diagnostic technologies and significant biomarkers that aid in this. Clinical trials and case studies within personalized therapy and drug development. Screening, prediction and prevention of disease, prediction of adverse events, treatment monitoring, effects of metabolomics and microbiomics on treatment. Secondary population research, genome-wide association studies, disease–gene association studies, personal genome technologies. Ethical and cost–benefit issues, the impact to healthcare and business infrastructure, and regulatory issues.