某三级医院肥胖与非肥胖儿童维生素D状况及对维生素D补充的反应评估

Q4 Medicine
Suraiya Begum, F. Sharmin, Kohinoor Jahan Shayamaly, D. Biswas, Anika Chowdhury, S. Parveen, Tanjida Chowdhury
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引用次数: 0

摘要

背景:肥胖似乎是当今的一个关键问题,因为它的高患病率和对健康的不利影响。有证据表明肥胖与血清25-羟基维生素D浓度降低有关。目的:本研究的目的是评估肥胖和非肥胖儿童在补充维生素D后的维生素D状况和对维生素D的反应。方法:本研究为准实验研究,于2018年8月至2019年2月在Bangabandhu sheikh Mujib医科大学(BSMMU)儿科内分泌科门诊和儿科户外科完成。研究人员测量了20名10-18岁的肥胖儿童和20名非肥胖儿童的维生素D含量。所有(100%)肥胖儿童和15(75%)非肥胖儿童出现维生素D缺乏症。肥胖和非肥胖的维生素D缺乏儿童每天口服4000国际单位,持续3个月。补充维生素D前后测定血清维生素D、钙、无机磷酸盐、碱性磷酸酶(ALP)和甲状旁腺激素(PTH)水平。结果:肥胖儿童平均年龄为11.64±1.40岁,非肥胖儿童平均年龄为11.15±2.40岁,男女比例为1:1.3。肥胖儿童中维生素D缺乏症发生率为100%,非肥胖儿童中为75%。肥胖儿童中维生素D缺乏(VDD)占85%,维生素D不足(VDI)占15%。非肥胖儿童VDD发生率为86.7%,VDI发生率为13.3%。每天补充4000 IU维生素D 3个月后,两组血清维生素D水平均显著升高,碱性磷酸酶和甲状旁腺激素水平显著降低,血清钙升高,血清无机磷酸酶降低,但均无统计学意义。补充维生素D后,60%的肥胖儿童和53.3%的非肥胖儿童的维生素D状态正常,30%的肥胖/超重儿童和26.7%的非肥胖儿童的VDI正常,10%的肥胖/超重儿童和20%的非肥胖儿童的VDD正常。结论:肥胖儿童和非肥胖儿童均存在VDD。在两个组中,观察到每天补充4000 IU维生素D三个月的治疗效果。孟加拉国医疗援助理事会2022年公报;48: 90 - 96
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Assessment of Vitamin D Status and Response to Vitamin D Supplementation in Obese and Non-obese Children at a Tertiary Care Hospital
Background: Obesity seems to be a critical issue nowadays because of its high prevalence and its adverse effects on health. There is some evidence indicating the relationship between obesity and lower serum 25- hydroxyvitamin D concentration. Objectives: The objectives of this study were to assess the vitamin D status and estimate the response to vitamin D in obese and non-obese children after vitamin D supplementation. Methods: This was a Quasi experimental study, done in Paediatric Endocrinology Clinic and Paediatric Outdoor, Bangabandhu Shiekh Mujib Medical University (BSMMU) from August 2018 to February 2019. Vitamin D was measured in 20 obese and 20 non-obese children aged 10-18 years. Hypovitaminosis D was observed in all (100%) obese children and 15 (75%) non-obese children. Four thousand IU was given orally daily in obese and non-obese vitamin D deficient children for 3 months. Serum levels of vitamin D, calcium, inorganic phosphate, Alkaline Phosphatase (ALP) and Parathormone (PTH) also measured before and after vitamin D supplementation. Results: The mean age was 11.64±1.40 years in obese and11.15±2.40 years in non-obese children, and male female ratio was 1:1.3. Hypovitaminosis D was present in 100% in obese and 75% in non-obese children. Vitamin D deficiency (VDD) was observed in 85% and vitamin D insufficiency (VDI) was in 15% in obese children. In non-obese children VDD was observed in 86.7% and VDI in 13.3% cases. In both the groups serum vitamin D was increased, alkaline phosphatase and parathormone levels were decreased significantly, and serum calcium was increased and serum inorganic phosphatase was decreased but not statistically significant after four thousand IU daily vitamin D supplementation for three months. After vitamin D supplementation, vitamin D status were found normal in 60% obese and 53.3% non-obese children, VDI were in 30% obese/overweight and 26.7% in non-obese children, and VDD were in 10% obese/overweight and 20% in non-obese children. Conclusion: VDD was observed in both obese and non-obese children. Therapeutic responses were observed with 4000 IU/day vitamin D supplementation for three months in both the groups. Bangladesh Medical Res Counc Bull 2022; 48: 90-96
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来源期刊
CiteScore
0.30
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0.00%
发文量
48
期刊介绍: The official publication of the Bangladesh Medical Research Council.
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