环状膜后进气道贴片a型患者的患病率、临床特征和治疗反应

IF 0.4 Q4 GASTROENTEROLOGY & HEPATOLOGY
I. Ali, Abhijith Bale, U. Jalihal, Praveen Kumar A. C., Ajay Bale, Meghana Sreenath
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引用次数: 0

摘要

【摘要】目的了解环状膜后入口贴片(PC-IP)的发生率,评价其临床特征、病理特征及治疗效果。材料与方法回顾性横断面研究于2016年4月至2021年4月在印度城市三级胃肠病学单位进行。所有有球感、慢性咳嗽、胃灼热、声音嘶哑、喉咙痛、吞咽困难和反酸等症状的患者在经过彻底的临床检查后,由经验丰富的内窥镜医师进行食管胃十二指肠镜检查,包括活检。研究期间记录了社会人口统计数据、症状及其持续时间、既往医院就诊情况和慢性质子泵抑制剂(PPI)使用情况。结果在研究期间共进行了三千二百五十次上消化道内镜检查。PC-IP患病率为2.7%,其中男性占36.3%,其余为女性。平均年龄36.2±17岁。这些患者最常见的症状是球感(81.8%),其次是反酸(75%)、消化不良(64.7%)、吞咽困难(48.8%)、喉咙痛(29.54%)、慢性咳嗽(22.72%)、声音沙哑(22.72%)和其他(6.81%)。PC-IP平均直径为1.5±0.5 cm,超过1个贴片的患者占23.76%。组织病理学检查显示异养型胃黏膜占77.27%,其中38.23%为氧合型,44.11%为黏液型,其余为混合细胞型。中位随访20个月后,68.18%的患者有持续症状,77.27%的患者对PPI有反应,22.73%的患者对PPI难治。在随访中,38.63%的患者进行了重复内镜手术和活检(20.45%);没有显示出任何大小变化或发育不良。结论PC-IP患病率可能高于预期。仔细检查食管上部并使用窄带成像将增加识别IP的可能性。那些有症状的患者需要用PPI治疗,有时需要长期治疗。射频消融治疗或氩等离子凝固治疗需要进一步澄清。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Prevalence, Clinical Characteristics, and Treatment Response in Patients with Post Cricoid Inlet Patch—A Descriptive Retrospective Study
Abstract Objectives  The aim of this study was to determine the incidence of post cricoid inlet patch (PC-IP) and to assess the clinical characteristics, pathological features, and treatment response. Materials and Methods  A retrospective cross-sectional study was conducted from April 2016 to April 2021 in the tertiary gastroenterology unit of urban India. All patients with symptoms of globus sensation, chronic cough, heartburn, hoarseness, throat pain, dysphagia, and acid regurgitation after a thorough clinical examination underwent esophagogastroduodenoscopy by experienced endoscopists including biopsy. Sociodemographic data, symptoms and its duration, previous hospital visits, and chronic proton pump inhibitor (PPI) use were noted during the study. Results   Three-thousand two-hundred fifty upper gastrointestinal endoscopies were performed during the study period. The prevalence of PC-IP was 2.7%, comprising 36.3% males and rest females. Mean age was 36.2 ± 17years. The most common symptom among these patients was globus sensation (81.8%) followed by acid regurgitation (75%), dyspepsia (64.7%), dysphagia (48.8%), throat pain (29.54%), chronic cough (22.72%), hoarseness (22.72%), and others (6.81%). Mean diameter of PC-IP was 1.5 ± 0.5 cm, more than one patch was found in 23.76% of patients. Histopathological examination showed heterotrophic gastric mucosa in 77.27%, out of which 38.23% had oxyntic type, 44.11% had mucoid type, and the rest had mixed cell type. On median follow-up after 20 months, 68.18% of patient had persistent symptoms, 77.27% were PPI responsive, and 22.73% were PPI refractory. On follow-up, 38.63% of patients had a repeat endoscopic procedure and biopsy (20.45%); none showed any changes in size or dysplasia. Conclusion  Prevalence of PC-IP could be higher than the estimated. Careful examination of upper esophagus and use of narrow band imaging will increase the possibility of identifying IP. Those symptomatic patients need treatment with PPI, sometimes for long term. Ablative therapy with radiofrequency or argon plasma coagulation needs further clarification.
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来源期刊
Journal of Digestive Endoscopy
Journal of Digestive Endoscopy GASTROENTEROLOGY & HEPATOLOGY-
自引率
28.60%
发文量
35
审稿时长
22 weeks
期刊介绍: The Journal of Digestive Endoscopy (JDE) is the official publication of the Society of Gastrointestinal Endoscopy of India that has over 1500 members. The society comprises of several key clinicians in this field from different parts of the country and has key international speakers in its advisory board. JDE is a double-blinded peer-reviewed, print and online journal publishing quarterly. It focuses on original investigations, reviews, case reports and clinical images as well as key investigations including but not limited to cholangiopancreatography, fluoroscopy, capsule endoscopy etc.
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