2014 - 2019年克拉斯诺达尔地区HIV-1耐药突变基因谱及特征分析

Q4 Medicine

HIV Infection and Immunosuppressive Disorders Pub Date : 2022-08-30 DOI:10.22328/2077-9828-2022-14-2-20-30

А. Antonova, А. S. Tumanov, А. V. Lebedev, Е. V. Kozyennova, L. N. Glinkina, V. Kulagin, А. B. Shemshura, P. V. Lebedev, L. V. Khoteleva, M. Bobkova

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引用次数: 2

摘要

客观的2014年至2019年在克拉斯诺达尔地区传播的AIDS-1的分子遗传学分析，包括耐药性突变的分析材料和方法。该研究使用了2014年至2019年期间居住在克拉斯诺达尔地区的478名艾滋病毒感染者的样本；其中155人接受了抗逆转录病毒治疗。对获得的样本进行了基因分型和进一步的系统发育分析，包括对已鉴定的独特重组形式的HIV-1进行了详细分析。结果表明，HIV-1亚型A6（80.5%）在克拉斯诺达尔地区继续占主导地位，遗传变体B（9.2%）是第二常见的变体。此外，还发现了11种独特的重组形式（URF），其中10种是A6和B基因变体重组的结果。114名接受抗逆转录病毒治疗的患者登记了耐药性突变（73,6%）；主要突变——M184V和A62V。幼稚患者群体中传播性耐药性的临时指标为4.6%（15/323）；主要突变K103NиG190S。结论2014年至2019年，在克拉斯诺达尔地区进行了基因图谱和HIV-1耐药性突变分析。

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Genetic profile and characteristics of HIV-1 drug resistance mutation in the Krasnodar region over the 2014 to 2019

Objective. Molecular genetic analysis of AIDS-1, having spread in the territory of Krasnodar region over the 2014 to 2019, including analysis of drug resistance mutationMaterials and methods. The study used the collection of samples, obtained from 478 HIV-infected people, living in the territory of Krasnodar region over the 2014 to 2019; out of them 155 received antiretroviral therapy (ART). Genotyping of the obtained samples was carried out with the further phylogenetic analysis, including detailed analysis of identified unique recombinant forms of HIV-1.Results. It is shown that HIV-1 sub-subtype A6 (80,5%) continues dominating in the territory of Krasnodar region, genetic variant B (9,2%) is the second most common one. Also 11 unique recombinant forms (URFs) were discovered, 10 out of which are the result of A6 and B genetic variants recombination. Drug resistance mutations were registered with 114 patients, received ART (73,6%); primary mutations — M184V and A62V. Provisional indicator of transmissible drug resistance in the population of naïve patients is 4,6% (15/323); primary mutations — K103N и G190S. Conclusion. The analysis of genetic profile and HIV-1 drug resistance mutation is carried out in the territory of Krasnodar region over the 2014 to 2019.

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来源期刊

HIV Infection and Immunosuppressive Disorders Medicine-Infectious Diseases

CiteScore

0.70

自引率

0.00%

发文量

期刊介绍： In the scientific-practical journal "HIV Infection and Immunosuppressive Disorders", published various issues of HIV medicine (epidemiology, molecular mechanisms of pathogenesis to the development of educational programs) leading scientists of Russia and countries of CIS, USA, as well as practical healthcare professionals working in research centers, research institutes, universities, clinics where done basic medical work. A special place on the pages of the publication is given to basic and clinical research, analytical reviews of contemporary and foreign reports, the provision of medical care for various diseases.