{"title":"动脉粥样硬化背景下脑血管疾病平滑肌和内皮细胞的增殖和凋亡与免疫炎症","authors":"D. S. Mankovskiy, N. Chuiko, O. Kuryk","doi":"10.37897/rjn.2022.1.5","DOIUrl":null,"url":null,"abstract":"The aim – to determine the role of vascular wall cells proliferation and apoptosis with the participation of immune inflammation, and their impact on the development of cerebrovascular disease (CVD) development on the atherosclerosis (AS) background. Materials and methods. We studied 50 cases of death with ischemic stroke and 50 cases of death with hemorrhagic stroke on the cerebral vessels AS background. Outcomes. Lymphocytes are one of the atheroma components and are mainly localised at the sites of plaque rupture in close contact with macrophages and smooth muscle cells. Smooth muscle cells are able to synthesize important collagen and elastin for the vascular wall, but potentiated apoptosis of smooth muscle cells may contribute to destabilisation and plaque rupture. Smooth muscle cells apoptosis was triggered by proinflammatory factors and took place with the participation of cytotoxic T-lymphocytes (T-killers) therefore in the atherosclerotic lesions focus we registered an accumulation of multitude cytotoxic T-lymphocytes. Conclusions. The macrophages and smooth muscle cells susceptibility to apoptosis was significantly higher directly in the atheroma, but macrophage apoptosis is a useful process for the atherosclerotic plaque stability. Desquamation and endothelial cell apoptosis are interrelated processes that play an important role in atheromatous plaque formation.","PeriodicalId":37662,"journal":{"name":"Romanian Journal of Neurology/ Revista Romana de Neurologie","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2022-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Proliferation and apoptosis of smooth muscle and endothelial cells with immune inflammation in cerebrovascular diseases on atherosclerosis background\",\"authors\":\"D. S. Mankovskiy, N. Chuiko, O. Kuryk\",\"doi\":\"10.37897/rjn.2022.1.5\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The aim – to determine the role of vascular wall cells proliferation and apoptosis with the participation of immune inflammation, and their impact on the development of cerebrovascular disease (CVD) development on the atherosclerosis (AS) background. Materials and methods. We studied 50 cases of death with ischemic stroke and 50 cases of death with hemorrhagic stroke on the cerebral vessels AS background. Outcomes. Lymphocytes are one of the atheroma components and are mainly localised at the sites of plaque rupture in close contact with macrophages and smooth muscle cells. Smooth muscle cells are able to synthesize important collagen and elastin for the vascular wall, but potentiated apoptosis of smooth muscle cells may contribute to destabilisation and plaque rupture. Smooth muscle cells apoptosis was triggered by proinflammatory factors and took place with the participation of cytotoxic T-lymphocytes (T-killers) therefore in the atherosclerotic lesions focus we registered an accumulation of multitude cytotoxic T-lymphocytes. Conclusions. The macrophages and smooth muscle cells susceptibility to apoptosis was significantly higher directly in the atheroma, but macrophage apoptosis is a useful process for the atherosclerotic plaque stability. Desquamation and endothelial cell apoptosis are interrelated processes that play an important role in atheromatous plaque formation.\",\"PeriodicalId\":37662,\"journal\":{\"name\":\"Romanian Journal of Neurology/ Revista Romana de Neurologie\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-03-31\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Romanian Journal of Neurology/ Revista Romana de Neurologie\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.37897/rjn.2022.1.5\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Romanian Journal of Neurology/ Revista Romana de Neurologie","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.37897/rjn.2022.1.5","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
Proliferation and apoptosis of smooth muscle and endothelial cells with immune inflammation in cerebrovascular diseases on atherosclerosis background
The aim – to determine the role of vascular wall cells proliferation and apoptosis with the participation of immune inflammation, and their impact on the development of cerebrovascular disease (CVD) development on the atherosclerosis (AS) background. Materials and methods. We studied 50 cases of death with ischemic stroke and 50 cases of death with hemorrhagic stroke on the cerebral vessels AS background. Outcomes. Lymphocytes are one of the atheroma components and are mainly localised at the sites of plaque rupture in close contact with macrophages and smooth muscle cells. Smooth muscle cells are able to synthesize important collagen and elastin for the vascular wall, but potentiated apoptosis of smooth muscle cells may contribute to destabilisation and plaque rupture. Smooth muscle cells apoptosis was triggered by proinflammatory factors and took place with the participation of cytotoxic T-lymphocytes (T-killers) therefore in the atherosclerotic lesions focus we registered an accumulation of multitude cytotoxic T-lymphocytes. Conclusions. The macrophages and smooth muscle cells susceptibility to apoptosis was significantly higher directly in the atheroma, but macrophage apoptosis is a useful process for the atherosclerotic plaque stability. Desquamation and endothelial cell apoptosis are interrelated processes that play an important role in atheromatous plaque formation.
期刊介绍:
ROMANIAN JOURNAL OF NEUROLOGY (Revista Română de Neurologie), the official journal of the Romanian Society of Neurology, was founded in 2001, being a prestigious scientific journal that provides a high quality in terms of scientific content, but also the editorial and graphic aspect, both through an impartial process of selection, evaluation and correction of articles (peer review procedure), as well as providing editorial, graphic and printing conditions at the highest level. In order to increase the scientific standards of the journal, special attention was paid to the improvement of the quality of the published materials. Guidance articles, clinical trials and case studies are structured in several sections: reviews, original articles, case reports, images in neurology. All articles are published entirely in English. A team of reputable medical professionals in the field of neurology is involved in a rigorous peer review process that complies with international ethics and quality rules in the academic world.