聚氨酯水凝胶、聚氨酯气凝胶和聚氨酯-石墨烯纳米复合材料的生物医学应用。

Q3 Psychology
S. Saganuwan
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引用次数: 0

摘要

背景新出现的健康问题的增加对现代医学的治疗提出了挑战。因此,包括多元醇、共聚物和填充剂的聚氨酯水凝胶可以由具有佐剂(如抗坏血酸、山梨醇等)的各种化合物制备。它们的机械物理化学性质是其生物活性的函数。因此,有必要评估它们的治疗潜力。方法对聚氨酯-水凝胶、聚氨酯-气凝胶和聚氨酯-石墨烯纳米复合材料的合成和医学应用进行了研究,以确定其来源、合成、机械和理化性能、生物医学应用、手性,以及Lipinski五定律在口腔聚氨酯纳米复合材料合成中的相关性。结果制备的水凝胶和气凝胶可作为皮内、皮肤和鼻内药物的聚合物载体。它们可以被制造并用作假肢。此外,聚氨酯水凝胶和气凝胶的强度模量(拉伸应力-拉伸应变比)、生物降解性、生物相容性和无毒性是非常理想的性能。然而,身体和环境温度可能会导致它们的不稳定性,因此需要改进可以持续多年的气凝胶和聚氨酯水凝胶的合成。酗酒、糖尿病、热原性疾病、机械力和物理力以及生理变异性也可能缩短聚氨酯气凝胶和水凝胶的寿命。结论合成聚氨酯-水凝胶-气凝胶复合物,可用于复杂、罕见的生物医学案例,具有极其重要的意义。根据结构成分和预期的生物医学用途,这些水凝胶和气凝胶可以是疏水的、亲水的、疏气的、亲气的或两亲的,有时是亲油的。聚氨酯-石墨烯纳米复合材料用于治疗多种疾病,包括癌症和细菌感染。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Biomedical Applications of Polyurethane Hydrogels, Polyurethane Aerogels and Polyurethane-Graphene Nanocomposite Materials.
BACKGROUND Increasing new emerging ill-healths have posed therapeutic challenges in modern medicine. Hence polyurethane hydrogels that comprise polyol, copolymer and extender could be prepared from diverse chemical compounds with adjuvants such as ascorbic acid, sorbitol among others. Their mechano-physicochemical properties are functions of their biological activities. Therefore there is need to assess their therapeutic potentials. METHODS literature were searched on synthesis and medical uses of polyurethane - hydrogels, polyurethane - aerogels and polyurethane - graphene nanocomposite materials, with a view to identifying their sources, synthesis, mechanical and physiochemical properties, biomedical applications, chirality, and the relevance of Lipinski's rule of five in the synthesis of oral polyurethane nanocomposite materials. RESULTS The prepared hydrogels and aerogels could be used as polymer carriers for intradermal, cutaneous and intranasal drugs. They can be fabricated and used as prosthetics. In addition the strength modulus (tensile stress-tensile strain ratio), biodegradability, biocompatibility and non-toxic effects of the polyurethane hydrogels and aerogels are the highly desirable properties. However, body and environmental temperatures may contribute to their instability, hence there is need to improve on the synthesis of aerogels and hydrogels of polyurethane that can last for many years. Alcoholism, diabetes, pyrogenic diseases, mechanical and physical forces, and physiological variability may also reduce the life span of polyurethane aerogels and hydrogels. CONCLUSION Synthesis of polyurethane hydrogel-aerogel complex that can be used in complex, rare biomedical cases is of paramount importance. These hydrogels and aerogels may be hydrophobic, hydrophilic, aerophobic-aerophilic or amphiphilic and sometimes lipophilic depending on structural components and the intended biomedical uses. Polyurethane graphene nanocomposite materials are used in the treatment of a myriad of diseases including cancer and bacterial infection.
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来源期刊
Central nervous system agents in medicinal chemistry
Central nervous system agents in medicinal chemistry Psychology-Neuropsychology and Physiological Psychology
CiteScore
2.10
自引率
0.00%
发文量
21
期刊介绍: Central Nervous System Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of new central nervous system agents. Containing a series of timely in-depth reviews written by leaders in the field covering a range of current topics, Central Nervous System Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments in the field.
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