糖尿病脂质坏死性坏死是糖尿病的征兆

Pub Date : 2018-03-01 DOI:10.12816/0047470
Alanood Al-Meraisel, Hana Al-Khayat
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引用次数: 0

摘要

NLD是一种发生在小腿的皮肤疹。平均发病年龄为30至40岁,但它可以出现在任何年龄,而且在糖尿病患者中往往发生得更早;女性患此病的几率是男性的三倍。全国民主联盟发展为一个微微凸起的有光泽的红棕色斑块,中心呈黄色。通常情况下,会出现多个补丁,并可能发展成开放性溃疡,需要很长时间才能愈合;它通常被很容易在皮肤下看到的血管包围(毛细血管扩张)。人们提出了许多病因学理论,但确切的病因尚不清楚。然而,最被接受的理论是,这是由于血管紊乱,包括免疫复合物沉积或微血管病变改变,导致胶原变性。NLD通常发生在糖尿病患者、糖尿病家族史或糖尿病易感人群中。NLD可能与类似的情况相混淆,例如环状肉芽肿,它表现为单个斑点,通常由红色到棕色的圆形阵列和稍微半透明的肿块组成。其他类似的情况包括脂质皮肤硬化、坏死性黄色肉芽肿和糖尿病性皮肤病。皮肤
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Necrobiosis Lipoidica Diabeticorum as a Sign of Diabetes
NLD is a type of skin eruptions that occur on the lower legs. The average age of onset is 30 to 40 years, but it could present at any age and tends to occur earlier in diabetics; it is three times more common in females than males. NLD develops as a slightly raised shiny red-brown patch with a yellowish center. Typically, multiple patches develop and might progress to open sores that take a long time to heal; it is usually surrounded by blood vessels that are easily visible under the skin (telangiectasia)2. Many etiological theories have been proposed, but the exact cause is unknown. Nevertheless, the most accepted theory is that it is due to a vascular disturbance involving immune complex deposition or microangiopathic changes resulting in collagen degeneration. NLD usually occurs in people with diabetes mellitus, family history of diabetes or those predisposed to diabetes. NLD could be confused with similar conditions, such as Granuloma Annulare, which appears as individual spots, usually consisting of a circular array of reddish to brown and slightly translucent bumps. Other similar conditions include lipodermatosclerosis, necrobiotic xanthogranuloma, and diabetic dermopathy. Skin
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