简介：免疫相关动物模型：机遇与挑战。

IF 3.1 3区农林科学 Q1 VETERINARY SCIENCES

Ilar Journal Pub Date : 2018-12-31 DOI:10.1093/ilar/ilz014

G. Jungersen, J. Piedrahita

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引用次数: 0

摘要

免疫学相关临床挑战中临床前动物模型的有效解释对于解决突出的临床需求至关重要。然而，考虑到免疫系统的整体复杂性以及物种和组织特异性免疫特性，选择和设计适当的免疫相关动物模型并不是一条简单的道路。本期ILAR杂志的主题评估了肿瘤、造血、CAR-T细胞和异种移植、佐剂和传染病以及免疫特异性炎症中使用的免疫相关动物模型，这些模型为未满足的人类临床需求提供了关键见解。

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INTRODUCTION: Immune Relevant Animal Models: Opportunities and Challenges.

Valid interpretation of preclinical animal models in immunology-related clinical challenges is important to solve outstanding clinical needs. Given the overall complexity of the immune system and both species- and tissue-specific immune peculiarities, the selection and design of appropriate immune-relevant animal models is, however, not following a straightforward path. The topics in this issue of the ILAR Journal provide assessments of immune-relevant animal models used in oncology, hematopoietic-, CAR-T cell- and xenotransplantation, adjuvants and infectious diseases, and immune privileged inflammation that are providing key insights into unmet human clinical needs.

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来源期刊

Ilar Journal 农林科学-兽医学

CiteScore

5.10

自引率

20.00%

发文量

审稿时长

>18 weeks

期刊介绍： The ILAR Journal is the peer-reviewed, theme-oriented publication of the Institute for Laboratory Animal Research (ILAR), which provides timely information for all who study, use, care for, and oversee the use of animals in research. The journal publishes original articles that review research on animals either as direct subjects or as surrogates for humans. According to policy, any previously unpublished animal research reported in the ILAR Journal will have been conducted according to the scientific, technical, and humanely appropriate guidelines current at the time the research was conducted in accordance with the Guide for the Care and Use of Laboratory Animals or other guidance provided by taxonomically-oriented professional societies (e.g., American Society of Mammalogy) as referenced in the Guide.