停止核苷类似物治疗后需要肝移植的非肝硬化HBV患者的病毒再激活

IF 1.3 4区医学 Q4 INFECTIOUS DISEASES

Antiviral Therapy Pub Date : 2021-01-01 DOI:10.1177/13596535211042205

Han Zhang, Fang Chen, E. Giang, Fei Bao, G. Lauer, C. Marsh, M. Law, P. Pockros

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引用次数: 3

摘要

核苷(t)类似物(NAs)是治疗慢性乙型肝炎(CHB)感染的主要药物，对乙型肝炎病毒(HBV)抑制有深远的影响。我们报告一例罕见的乙型肝炎患者在停止NA治疗后无肝硬化，导致急性肝衰竭，需要肝移植。对病毒遗传学和宿主免疫反应的研究表明，已知促进病毒复制的病毒突变与再激活有关，而该患者对HBV的适应性免疫仍然存在缺陷。病毒测序可能有助于识别不利于停药的突变。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Virus reactivation in a non-cirrhotic HBV patient requiring liver transplantation after cessation of nucleoside analogue therapy

Nucleos(t)ide analogues (NAs) are a mainstay of therapy for chronic hepatitis B (CHB) infections and have a profound effect on hepatitis B virus (HBV) suppression. We report a rare case of HBV reactivation in a CHB patient without cirrhosis following cessation of NA therapy that resulted in acute liver failure requiring liver transplantation. Investigation of the viral genetics and host immune responses suggest that viral mutations known to promote virus replication are associated with reactivation, whereas adaptive immunity to HBV remained defective in this patient. Viral sequencing may be useful for identifying mutations that are unfavorable for therapy withdrawal.

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来源期刊

Antiviral Therapy 医学-病毒学

CiteScore

2.60

自引率

8.30%

发文量

审稿时长

4-8 weeks

期刊介绍： Antiviral Therapy (an official publication of the International Society of Antiviral Research) is an international, peer-reviewed journal devoted to publishing articles on the clinical development and use of antiviral agents and vaccines, and the treatment of all viral diseases. Antiviral Therapy is one of the leading journals in virology and infectious diseases. The journal is comprehensive, and publishes articles concerning all clinical aspects of antiviral therapy. It features editorials, original research papers, specially commissioned review articles, letters and book reviews. The journal is aimed at physicians and specialists interested in clinical and basic research.