Xuan Luo , Jing Peng , Kejian Huang , Xiaofeng Liu , Ning Yang , Qiulian Luo
{"title":"芬太尼类新型精神活性物质的电子电离-质谱特征片段和解理模式研究","authors":"Xuan Luo , Jing Peng , Kejian Huang , Xiaofeng Liu , Ning Yang , Qiulian Luo","doi":"10.1016/j.forc.2023.100518","DOIUrl":null,"url":null,"abstract":"<div><p>Fentanyl-type new psychoactive substances (fentanyl-type NPS) are the primary subclass of synthetic opioid groups in new psychoactive substances (NPS). According to <em>World Drug Report 2022</em> by the United Nations Office on Drugs and Crime, fentanyl-type NPS are the major cause of overdose deaths in North America, where their abuse is the most severe. Given the multiple modification sites in the structures of fentanyl-type NPS, the derivatization rate is very rapid, causing more difficulties for analysis and identification in forensic laboratories. Because the fragments in electron ionization-mass spectrometry (EI-MS) spectra contain rich structural information and similar compounds have similar MS cleavage patterns and produce similar characteristic fragments, it is crucial to infer the structure of emerging fentanyl-type NPS by summarizing the cleavage patterns and distinct fragments of fentanyl-type NPS EI-MS data. In this study, 49 fentanyl-type NPS were analyzed using gas chromatography-MS (GC–MS) with EI and chemical ionization sources. Subsequently, the EI-MS cleavage rules and characteristic fragments of fentanyl-type NPS were summarized with the assistance of 129 fentanyl-type NPS GC–MS data obtained from <span>www.caymanchem.com</span><svg><path></path></svg>. Furthermore, a set of structural analysis procedures was established to determine the structures of emerging fentanyl-type NPS. This procedure laid the foundation for rapid identification and screening of fentanyl-type NPS.</p></div>","PeriodicalId":324,"journal":{"name":"Forensic Chemistry","volume":"35 ","pages":"Article 100518"},"PeriodicalIF":2.6000,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Study on electron ionization-mass spectrometry characteristic fragments and cleavage patterns of fentanyl-type new psychoactive substances\",\"authors\":\"Xuan Luo , Jing Peng , Kejian Huang , Xiaofeng Liu , Ning Yang , Qiulian Luo\",\"doi\":\"10.1016/j.forc.2023.100518\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Fentanyl-type new psychoactive substances (fentanyl-type NPS) are the primary subclass of synthetic opioid groups in new psychoactive substances (NPS). According to <em>World Drug Report 2022</em> by the United Nations Office on Drugs and Crime, fentanyl-type NPS are the major cause of overdose deaths in North America, where their abuse is the most severe. Given the multiple modification sites in the structures of fentanyl-type NPS, the derivatization rate is very rapid, causing more difficulties for analysis and identification in forensic laboratories. Because the fragments in electron ionization-mass spectrometry (EI-MS) spectra contain rich structural information and similar compounds have similar MS cleavage patterns and produce similar characteristic fragments, it is crucial to infer the structure of emerging fentanyl-type NPS by summarizing the cleavage patterns and distinct fragments of fentanyl-type NPS EI-MS data. In this study, 49 fentanyl-type NPS were analyzed using gas chromatography-MS (GC–MS) with EI and chemical ionization sources. Subsequently, the EI-MS cleavage rules and characteristic fragments of fentanyl-type NPS were summarized with the assistance of 129 fentanyl-type NPS GC–MS data obtained from <span>www.caymanchem.com</span><svg><path></path></svg>. Furthermore, a set of structural analysis procedures was established to determine the structures of emerging fentanyl-type NPS. This procedure laid the foundation for rapid identification and screening of fentanyl-type NPS.</p></div>\",\"PeriodicalId\":324,\"journal\":{\"name\":\"Forensic Chemistry\",\"volume\":\"35 \",\"pages\":\"Article 100518\"},\"PeriodicalIF\":2.6000,\"publicationDate\":\"2023-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Forensic Chemistry\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2468170923000541\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, ANALYTICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Forensic Chemistry","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2468170923000541","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, ANALYTICAL","Score":null,"Total":0}
Study on electron ionization-mass spectrometry characteristic fragments and cleavage patterns of fentanyl-type new psychoactive substances
Fentanyl-type new psychoactive substances (fentanyl-type NPS) are the primary subclass of synthetic opioid groups in new psychoactive substances (NPS). According to World Drug Report 2022 by the United Nations Office on Drugs and Crime, fentanyl-type NPS are the major cause of overdose deaths in North America, where their abuse is the most severe. Given the multiple modification sites in the structures of fentanyl-type NPS, the derivatization rate is very rapid, causing more difficulties for analysis and identification in forensic laboratories. Because the fragments in electron ionization-mass spectrometry (EI-MS) spectra contain rich structural information and similar compounds have similar MS cleavage patterns and produce similar characteristic fragments, it is crucial to infer the structure of emerging fentanyl-type NPS by summarizing the cleavage patterns and distinct fragments of fentanyl-type NPS EI-MS data. In this study, 49 fentanyl-type NPS were analyzed using gas chromatography-MS (GC–MS) with EI and chemical ionization sources. Subsequently, the EI-MS cleavage rules and characteristic fragments of fentanyl-type NPS were summarized with the assistance of 129 fentanyl-type NPS GC–MS data obtained from www.caymanchem.com. Furthermore, a set of structural analysis procedures was established to determine the structures of emerging fentanyl-type NPS. This procedure laid the foundation for rapid identification and screening of fentanyl-type NPS.
期刊介绍：
Forensic Chemistry publishes high quality manuscripts focusing on the theory, research and application of any chemical science to forensic analysis. The scope of the journal includes fundamental advancements that result in a better understanding of the evidentiary significance derived from the physical and chemical analysis of materials. The scope of Forensic Chemistry will also include the application and or development of any molecular and atomic spectrochemical technique, electrochemical techniques, sensors, surface characterization techniques, mass spectrometry, nuclear magnetic resonance, chemometrics and statistics, and separation sciences (e.g. chromatography) that provide insight into the forensic analysis of materials. Evidential topics of interest to the journal include, but are not limited to, fingerprint analysis, drug analysis, ignitable liquid residue analysis, explosives detection and analysis, the characterization and comparison of trace evidence (glass, fibers, paints and polymers, tapes, soils and other materials), ink and paper analysis, gunshot residue analysis, synthetic pathways for drugs, toxicology and the analysis and chemistry associated with the components of fingermarks. The journal is particularly interested in receiving manuscripts that report advances in the forensic interpretation of chemical evidence. Technology Readiness Level: When submitting an article to Forensic Chemistry, all authors will be asked to self-assign a Technology Readiness Level (TRL) to their article. The purpose of the TRL system is to help readers understand the level of maturity of an idea or method, to help track the evolution of readiness of a given technique or method, and to help filter published articles by the expected ease of implementation in an operation setting within a crime lab.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
