Antibiotic Sensitivity in UTI among Diabetic Pregnant Women

Background: Urinary tract infection (UTI) is common during pregnancy and especially so in pregnant patients with diabetes mellitus. The emergence of drug resistance and particularly the extended spectrum Beta-lactamase production by Escherechia Coli and Methicillin resistance in staphylococci, limits the choice of anti-microbials. Method: A cross-sectional study was conducted on 50 pregnant women with sign and symptoms of UTI in the Department of Obstetrics and Gynaecology, BIRDEM general Hospital-2 from January to June 2017. The objectives of the study were to determine the presence and type of pathogens found in pregnant diabetic women presenting with features of urinary tract infection, and to analyze their antibiotic sensitivity pattern. Clean catch midstream urine samples were collected using standard procedure and culture and sensitivity was done following standard bacteriological method. Results: Mean age of the study subjects was 29.84±5.29 yrs; 48% were in third trimester of pregnancy; 52% had Gestational Diabetes Mellitus (GDM) and 48% had Diabetes Mellitus (DM). Out of fifty pregnant women, thirty eight (76.0%) study subjects had positive growth. Of them, Escherechia coli was found in 57.9% cases, Klebsiella in 21.1%, Staphylococcus aureus in 7.9%, Enterococcus and Pseudomonas aeruginosa each in 2.6% case. Amikacin was found to be sensitive to 100% cases of E. Coli, Klebsiella & Enterococcus but 100% resistant to Streptococcus. Conclusion: In this study, E. Coli was the most common organisms causing UTI, which is less susceptible to conventional oral antibiotics but more susceptible to amikacin. So carefull drug selection is required for successful outcome in UTI.