多裂肌细胞内脂质与慢性腰痛患者疼痛相关疾病、腰椎功能障碍、步态障碍之间的关系:一项使用日本骨科协会背痛评估问卷的横断面研究

I. Ogon, H. Takashima, T. Morita, M. Yoshimoto, Yasushi Fujita, T. Takebayashi, A. Teramoto
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引用次数: 0

摘要

背景与目的:脂肪变性在多裂肌(Mm)比其他躯干肌肉更常见。我们假设Mm的脂质含量与患者报告的生活质量(QOL)相关。然而,目前还没有使用磁共振波谱(MRS)检查Mm脂肪变性与患者报告的生活质量之间关系的论文。本横断面研究旨在探讨日本骨科协会背痛评估问卷(JOABPEQ)评估的患者报告的生活质量与MRS测量的慢性下腰痛(CLBP)患者Mm和psoas major (PM)的细胞内脂质(IMCL)和细胞外脂质(EMCL)含量之间的关系。材料与方法:48例患者(平均年龄64.2±13.2岁;年龄范围(41-79岁),非特异性CLBP患者行MRS,量化L4/L5感兴趣体积右侧Mm和PM的IMCL和EMCL。所有受试者均在同一天接受MRS检查并完成JOABPEQ。我们对Mm和PM的IMCL和EMCL含量进行了多元线性回归分析,并根据年龄、性别和体重指数调整了JOABPEQ的五个域。结果:Mm中IMCL含量与疼痛相关障碍(标准化偏回归系数(β)= - 0.59, p<0.01)、腰椎功能障碍(β= - 0.64, p<0.01)、社交生活障碍(β= - 0.31, p<0.01)呈中度负相关,与心理障碍无相关性。Mm的EMCL含量与JOABPEQ的5个结构域无关。PM的IMCL和EMCL含量与JOABPEQ的5个域不相关。结论:Mm中IMCL含量与疼痛相关障碍、腰椎功能障碍、步态障碍、JOABPEQ社交生活功能障碍域评分显著相关。未来对CLBP患者Mm的磁共振波谱研究可能有助于优化运动策略,并将IMCL作为提高患者报告的生活质量的指标。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Association Between Multifidus Intramyocellular Lipids and Pain-Related Disorders, Lumbar Spine Dysfunction, Gait Disturbance in Patients with Chronic Low Back Pain: A Cross-Sectional Study Using the Japanese Orthopaedic Association Back Pain Evaluation Questionnaire
Background and aims: Fat degeneration in the multifidus muscle (Mm) was more common than in other trunk muscles. We hypothesised that the lipid contents of the Mm and patient-reported quality of life (QOL) are related. However, there are no papers examining the association between fatty degeneration of the Mm and patient-reported QOL using magnetic resonance spectroscopy (MRS). This cross-sectional study aimed to investigate the association between patient-reported QOL, evaluated with the Japanese Orthopaedic Association Back Pain Evaluation Questionnaire (JOABPEQ), and the intramyocellular lipid (IMCL) and extramyocellular lipid (EMCL) contents of the Mm and psoas major (PM) by MRS in patients with chronic low back pain (CLBP). Materials and Methods: Forty-eight patients (mean age, 64.2 ± 13.2 years; age range, 41–79 years) with nonspecific CLBP underwent MRS for the quantification of IMCL and EMCL of the right Mm and PM in a volume of interest at L4/L5. All subjects underwent MRS and completed the JOABPEQ in the same day. We performed multiple linear regression analysis of the IMCL and EMCL contents of the Mm and PM with the five domains of the JOABPEQ adjusted for age, sex, and body mass index. Results: The IMCL content of the Mm was correlated with pain-related disorders (standardised partial regression coefficient (β)=−0.59, p<0.01), lumbar spine dysfunction (β=−0.64, p<0.01), and social life dysfunction (β=−0.31, p<0.01) which showed moderate negative correlation, but not with psychological disorders. The EMCL content of the Mm was not correlated with the five domains of the JOABPEQ. The IMCL and EMCL contents of the PM was not correlated with the five domains of the JOABPEQ. Conclusions: IMCL content of the Mm was significantly correlated with the pain-related disorders, lumbar spine dysfunction, gait disturbance, and social life dysfunction domain scores of the JOABPEQ. Future studies using magnetic resonance spectroscopy of the Mm in patients with CLBP may help optimize exercise strategies using IMCL as an index to enhance patient-reported quality of life.
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