琥珀酸乙基甲基羟基吡啶/维生素B6联合用药对新冠肺炎后综合征患者内皮功能指标的影响

Q3 Pharmacology, Toxicology and Pharmaceutics
L. V. Mikhailova, Y. Belousova, E. Moiseeva, Alina A. Tsapkova, N. Gazatova, Alexandra R. Plotnikova, Danila G. Rudev, Svetlana A. Doktorova, V. Rafalskiy
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引用次数: 1

摘要

新冠肺炎大流行后,公共卫生面临一个新问题,即症状持续存在,其中最显著的是过度疲劳。冠状病毒感染作为内皮疾病的定义提示衰弱综合征与内皮功能障碍之间可能存在关系。目的:评价新冠肺炎(COVID-19)患者联合使用EMHPS /维生素B6治疗前后内皮功能的变化。材料和方法:一项前瞻性研究包括33名参与者,女性82%,男性18%,年龄在22至68岁之间。在研究过程中进行了两次实地考察,两次考察之间有为期4周的治疗过程。结果:治疗后,内皮依赖性血管舒张指数女性升高,男性降低。这些差异在统计上不显著。治疗后内皮依赖性血管舒张正常的受试者由7例增加到11例。尽管女性倾向于降低血管壁硬度,而男性倾向于增加血管壁硬度,但血管壁硬度指数与受试者的平均年龄相对应,没有统计学上的变化。女性的一氧化氮初始水平较低,治疗后统计学上显著升高,而男性则保持不变。讨论:该研究证实了covid后病程延长。我们假设病毒破坏内皮细胞。已知内皮功能障碍与心血管风险增加有关。结论:该药治疗后内皮功能指标发生改变。有必要对更多的COVID-19患者进行内皮功能研究。图形抽象
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Dynamics of endothelial function indexes in patients with post-Covid syndrome using a combination drug of ethylmethylhydroxyperidine succinate/vitamin B6
Introduction: After the COVID-19 pandemic, public healthcare has faced a new problem, the persistence of symptoms, the most significant of which is undue fatigue. The definition of coronavirus infection as an endothelial disease suggests a possible relationship between asthenic syndrome and endothelial dysfunction. Aim: to evaluate endothelial function in patients after COVID-19 before and after treatment with combination drug of ethylmethylhydroxyperidine succinate (EMHPS)/vitamin B6. Materials and Methods: A prospective study included 33 participants, 82% women and 18% men aged 22 to 68 years after COVID-19. There were two site visits made in the course of the study and a 4-week treatment course between the visits. Results: After the treatment, the index of endothelium-dependent vasodilation increased in women and decreased in men. The differences were statistically insignificant. The number of subjects with a normal level of endothelium-dependent vasodilation increased from 7 to 11 after the treatment. The index of vascular wall stiffness corresponded to the mean age of the examined participants and did not statistically change, although women tended to decrease stiffness and men to increase it. The initial level of nitric oxide was lower in women and statistically significantly increased after treatment, while it remained unchanged in men. Discission: The study confirms a prolonged course of the post-covid. We assume that the virus destroys endothelial cells.Endothelial dysfunction is known to be associated with an increased cardiovascular risk. Conclusion: The indicators of endothelial function changed in patients after treatment with the drug. It is necessary to perform endothelial function studies in more patients after COVID-19. Graphical Abstract
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来源期刊
Research Results in Pharmacology
Research Results in Pharmacology Medicine-Pharmacology (medical)
CiteScore
1.50
自引率
0.00%
发文量
32
审稿时长
12 weeks
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