视网膜变性小鼠模型

Q4 Biochemistry, Genetics and Molecular Biology

Journal of Cellular Neuroscience and Oxidative Stress Pub Date : 2019-06-21 DOI:10.37212/JCNOS.584625

X. Shu

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引用次数: 0

摘要

视网膜是中枢神经系统的一部分。视网膜变性的特点是感光细胞死亡，导致部分视力丧失甚至失明。视网膜变性包括遗传性视网膜变性如视网膜色素变性（RP）和复杂的视网膜变性如糖尿病视网膜病变。在这次演讲中，我将讨论遗传性视网膜变性的发病机制和目前的治疗方法。我还将讨论在小鼠模型中进行视网膜变性的技术。我将演示如何解剖小鼠视网膜和视网膜色素上皮（RPE）细胞。

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Mouse models for retinal degeneration

Retina is a part of central nervous system. Retinal degeneration is characterized by the death of photoreceptor cells, causing partial vision loss or even blindness. Retinal degeneration includes inherited retinal degeneration such as retinitis pigmentosa (RP) and complex retinal degeneration such as diabetic retinopathy. In this talk, I will discuss the disease mechanisms and current treatment of inherited retinal degeneration. I will also discuss techniques for retinal degeneration in mouse models. I will demonstrate how to dissect mouse retina and retinal pigment epithelial (RPE) cells.

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来源期刊

Journal of Cellular Neuroscience and Oxidative Stress Biochemistry, Genetics and Molecular Biology-Biophysics

CiteScore

1.10

自引率

0.00%

发文量

期刊介绍： Journal of Cellular Neuroscience and Oxidative Stress isan online journal that publishes original research articles, reviews and short reviews on themolecular basisofbiophysical,physiological and pharmacological processes thatregulate cellular function, and the control or alteration of these processesby theaction of receptors, neurotransmitters, second messengers, cation, anions,drugsor disease. Areas of particular interest are four topics. They are; 1. Ion Channels (Na+-K+Channels, Cl– channels, Ca2+channels, ADP-Ribose and metabolism of NAD+,Patch-Clamp applications) 2. Oxidative Stress (Antioxidant vitamins, antioxidant enzymes, metabolism of nitric oxide, oxidative stress, biophysics, biochemistry and physiology of free oxygen radicals) 3. Interaction Between Oxidative Stress and Ion Channels in Neuroscience (Effects of the oxidative stress on the activation of the voltage sensitive cation channels, effect of ADP-Ribose and NAD+ on activation of the cation channels which are sensitive to voltage, effect of the oxidative stress on activation of the TRP channels in neurodegenerative diseases such Parkinson’s and Alzheimer’s diseases) 4. Gene and Oxidative Stress (Gene abnormalities. Interaction between gene and free radicals. Gene anomalies and iron. Role of radiation and cancer on gene polymorphism)