利用系统生物学将代谢分支与组蛋白尾部联系起来

IF 3.2 Q2 GENETICS & HEREDITY
S. Chandrasekaran
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引用次数: 1

摘要

组蛋白修饰代表了一种将营养状况与基因表达联系起来的先天细胞机制。代谢产物如乙酰辅酶A和S-腺苷甲硫氨酸通过充当组蛋白修饰的底物来影响基因表达。然而,我们缺乏一个基于细胞代谢状态确定组蛋白修饰水平的预测模型。与组蛋白标记交叉的众多代谢途径使得理解它们的相互依赖性极具挑战性。在这里,我们重点介绍了新的系统生物学工具,以揭示营养线索和代谢通量对组蛋白修饰的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Tying Metabolic Branches With Histone Tails Using Systems Biology
Histone modifications represent an innate cellular mechanism to link nutritional status to gene expression. Metabolites such as acetyl-CoA and S-adenosyl methionine influence gene expression by serving as substrates for modification of histones. Yet, we lack a predictive model for determining histone modification levels based on cellular metabolic state. The numerous metabolic pathways that intersect with histone marks makes it highly challenging to understand their interdependencies. Here, we highlight new systems biology tools to unravel the impact of nutritional cues and metabolic fluxes on histone modifications.
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来源期刊
Epigenetics Insights
Epigenetics Insights GENETICS & HEREDITY-
CiteScore
5.10
自引率
0.00%
发文量
10
审稿时长
8 weeks
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