{"title":"银/黑磷纳米片单分子的可视化SERS成像","authors":"Chenglong Lin, Shunshun Liang, Yusi Peng, Li Long, Yanyan Li, Zhengren Huang, Nguyen Viet Long, Xiaoying Luo, Jianjun Liu, Zhiyuan Li, Yong Yang","doi":"10.1007/s40820-022-00803-x","DOIUrl":null,"url":null,"abstract":"<div><h2>Highlights</h2><div>\n \n \n <ul>\n <li>\n <p>Ag/BP-NS exhibit remarkable surface-enhanced Raman scattering performance with single-molecule detection ability. This remarkable enhancement can be attributed to the synergistic resonance enhancement of R6G molecular resonance, photo-induced charge transfer resonance and electromagnetic resonance.</p>\n </li>\n <li>\n <p>A new polarization-mapping method was proposed, which can quickly screen out single-molecule signals and prove that the obtained spectra are emitted by single molecule.</p>\n </li>\n <li>\n <p>The recognition of different tumor exosomes can be realized combining the method of machine learning.</p>\n </li>\n </ul>\n \n <span>AbstractSection</span>\n Abstract\n <p>Single-molecule detection and imaging are of great value in chemical analysis, biomarker identification and other trace detection fields. However, the localization and visualization of single molecule are still quite a challenge. Here, we report a special-engineered nanostructure of Ag nanoparticles embedded in multi-layer black phosphorus nanosheets (Ag/BP-NS) synthesized by a unique photoreduction method as a surface-enhanced Raman scattering (SERS) sensor. Such a SERS substrate features the lowest detection limit of 10<sup>–20</sup> mol L<sup>−1</sup> for R6G, which is due to the three synergistic resonance enhancement of molecular resonance, photo-induced charge transfer resonance and electromagnetic resonance. We propose a polarization-mapping strategy to realize the detection and visualization of single molecule. In addition, combined with machine learning, Ag/BP-NS substrates are capable of recognition of different tumor exosomes, which is meaningful for monitoring and early warning of the cancer. This work provides a reliable strategy for the detection of single molecule and a potential candidate for the practical bio-application of SERS technology. </p><figure><div><div><div><picture><source><img></source></picture></div></div></div></figure>\n \n </div></div>","PeriodicalId":48779,"journal":{"name":"Nano-Micro Letters","volume":null,"pages":null},"PeriodicalIF":31.6000,"publicationDate":"2022-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s40820-022-00803-x.pdf","citationCount":"29","resultStr":"{\"title\":\"Visualized SERS Imaging of Single Molecule by Ag/Black Phosphorus Nanosheets\",\"authors\":\"Chenglong Lin, Shunshun Liang, Yusi Peng, Li Long, Yanyan Li, Zhengren Huang, Nguyen Viet Long, Xiaoying Luo, Jianjun Liu, Zhiyuan Li, Yong Yang\",\"doi\":\"10.1007/s40820-022-00803-x\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h2>Highlights</h2><div>\\n \\n \\n <ul>\\n <li>\\n <p>Ag/BP-NS exhibit remarkable surface-enhanced Raman scattering performance with single-molecule detection ability. This remarkable enhancement can be attributed to the synergistic resonance enhancement of R6G molecular resonance, photo-induced charge transfer resonance and electromagnetic resonance.</p>\\n </li>\\n <li>\\n <p>A new polarization-mapping method was proposed, which can quickly screen out single-molecule signals and prove that the obtained spectra are emitted by single molecule.</p>\\n </li>\\n <li>\\n <p>The recognition of different tumor exosomes can be realized combining the method of machine learning.</p>\\n </li>\\n </ul>\\n \\n <span>AbstractSection</span>\\n Abstract\\n <p>Single-molecule detection and imaging are of great value in chemical analysis, biomarker identification and other trace detection fields. However, the localization and visualization of single molecule are still quite a challenge. Here, we report a special-engineered nanostructure of Ag nanoparticles embedded in multi-layer black phosphorus nanosheets (Ag/BP-NS) synthesized by a unique photoreduction method as a surface-enhanced Raman scattering (SERS) sensor. Such a SERS substrate features the lowest detection limit of 10<sup>–20</sup> mol L<sup>−1</sup> for R6G, which is due to the three synergistic resonance enhancement of molecular resonance, photo-induced charge transfer resonance and electromagnetic resonance. We propose a polarization-mapping strategy to realize the detection and visualization of single molecule. In addition, combined with machine learning, Ag/BP-NS substrates are capable of recognition of different tumor exosomes, which is meaningful for monitoring and early warning of the cancer. This work provides a reliable strategy for the detection of single molecule and a potential candidate for the practical bio-application of SERS technology. </p><figure><div><div><div><picture><source><img></source></picture></div></div></div></figure>\\n \\n </div></div>\",\"PeriodicalId\":48779,\"journal\":{\"name\":\"Nano-Micro Letters\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":31.6000,\"publicationDate\":\"2022-03-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://link.springer.com/content/pdf/10.1007/s40820-022-00803-x.pdf\",\"citationCount\":\"29\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nano-Micro Letters\",\"FirstCategoryId\":\"88\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s40820-022-00803-x\",\"RegionNum\":1,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"MATERIALS SCIENCE, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nano-Micro Letters","FirstCategoryId":"88","ListUrlMain":"https://link.springer.com/article/10.1007/s40820-022-00803-x","RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}
Visualized SERS Imaging of Single Molecule by Ag/Black Phosphorus Nanosheets
Highlights
Ag/BP-NS exhibit remarkable surface-enhanced Raman scattering performance with single-molecule detection ability. This remarkable enhancement can be attributed to the synergistic resonance enhancement of R6G molecular resonance, photo-induced charge transfer resonance and electromagnetic resonance.
A new polarization-mapping method was proposed, which can quickly screen out single-molecule signals and prove that the obtained spectra are emitted by single molecule.
The recognition of different tumor exosomes can be realized combining the method of machine learning.
AbstractSection
Abstract
Single-molecule detection and imaging are of great value in chemical analysis, biomarker identification and other trace detection fields. However, the localization and visualization of single molecule are still quite a challenge. Here, we report a special-engineered nanostructure of Ag nanoparticles embedded in multi-layer black phosphorus nanosheets (Ag/BP-NS) synthesized by a unique photoreduction method as a surface-enhanced Raman scattering (SERS) sensor. Such a SERS substrate features the lowest detection limit of 10–20 mol L−1 for R6G, which is due to the three synergistic resonance enhancement of molecular resonance, photo-induced charge transfer resonance and electromagnetic resonance. We propose a polarization-mapping strategy to realize the detection and visualization of single molecule. In addition, combined with machine learning, Ag/BP-NS substrates are capable of recognition of different tumor exosomes, which is meaningful for monitoring and early warning of the cancer. This work provides a reliable strategy for the detection of single molecule and a potential candidate for the practical bio-application of SERS technology.
期刊介绍:
Nano-Micro Letters is a peer-reviewed, international, interdisciplinary and open-access journal that focus on science, experiments, engineering, technologies and applications of nano- or microscale structure and system in physics, chemistry, biology, material science, pharmacy and their expanding interfaces with at least one dimension ranging from a few sub-nanometers to a few hundreds of micrometers. Especially, emphasize the bottom-up approach in the length scale from nano to micro since the key for nanotechnology to reach industrial applications is to assemble, to modify, and to control nanostructure in micro scale. The aim is to provide a publishing platform crossing the boundaries, from nano to micro, and from science to technologies.