桥本甲状腺炎患者根据甲状腺状态的心血管风险:一项横断面研究

Karina Gómez, Yasmin Céspedes, Emily Rodriguez
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引用次数: 0

摘要

目的:探讨心血管危险因素和心血管危险评分与桥本甲状腺炎患者甲状腺状况的关系。方法:38名患有桥本甲状腺炎的成年人参与了这项横断面研究。考虑的心血管风险因素包括年龄、性别、血压、体重指数、快速血糖、血脂、心血管合并症、C反应蛋白和红细胞沉降率。进行Framingham CV风险评分。样本分为甲状腺功能正常(n=15)、临床甲状腺功能减退(n=9)和亚临床甲状腺功能低下(n=13),并包括抗甲状腺抗体的存在。Fisher精确检验用于确定所研究变量之间的相关性。结果:100%的样本为女性;平均年龄在39-59岁之间。低风险类别最多(n=30),相当于78.9%;中度风险,无患者;高危(n=8)占21.1%。临床甲状腺功能减退患者的年龄与CV风险评分之间存在统计学意义(p<0.01),95%CI。亚临床甲状腺功能低下和临床甲状腺功能减低患者的血糖水平具有统计学意义。抗甲状腺球蛋白(antiTg)的存在与亚临床甲状腺功能减退患者的CV风险水平密切相关。结论:年龄、血糖、抗Tg、糖尿病史、血脂异常或脑血管意外与10年内患CVD的风险增加有关,这取决于他们的甲状腺状况。在本研究的参与者中,没有发现CV风险评分与甲状腺状态之间存在直接关系的证据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Cardiovascular risk in Hashimoto thyroiditis patients according to their thyroid state: a cross-sectional study
Aims: To investigate the association between cardiovascular risk factors and cardiovascular risk score with the thyroid status of patients with Hashimoto’s Thyroiditis. Methods: Thirty-eight consenting adults with Hashimoto’s Thyroiditis participated in this cross-sectional study. The cardiovascular risk factors considered included age, sex, blood pressure, body mass index, fast blood glucose, lipid profile, cardiovascular comorbidities, C reactive protein, and erythrocyte sedimentation rate. The Framingham CV risk score was performed. The sample was classified into euthyroid (n = 15), clinical hypothyroidism (n = 9), and subclinical hypothyroidism (n = 13), and included the presence of antithyroid antibodies. Fisher’s exact test was used to determine the association between the variables studied. Results: 100% of the sample were women; a mean age between 39-59 years old. The category with low risk was the largest (n = 30), equivalent to 78.9%; moderate risk, no patient was obtained; high risk (n = 8) constituted 21.1%. Statistical significance between age and CV risk score in patients with clinical hypothyroidism was found (p < 1), 95% CI. The glucose level in the subclinical hypothyroidism and clinical hypothyroidism had statistical significance. The presence of anti-Thyroglobulin (antiTg) was shown to be closely related to the level of CV risk in patients with subclinical hypothyroidism. Conclusion: Age, glycemia, anti-Tg, history of DM, dyslipidemia, or cerebrovascular accidents have been linked to raising the risk of developing CVD in up to 10 years depending on their thyroid profile. No evidence of a direct relationship between CV risk score and thyroid state was found in the participants of this study.
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