大鼠肱骨年龄相关的组织形态学变化

Hussien Elkhateeb, Elsayed S. I. Mohammed, Dalia Mohamedien, Y. Ahmed, S. Soliman
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引用次数: 0

摘要

先前的研究将长骨生长分为膜内骨化和软骨内骨化。后者通过在物理生长板处添加新的骨组织来促进纵向骨生长。骨骼的厚度也通过皮质骨的同位骨生长而增加。本研究的目的是研究作为长骨模型的大鼠肱骨生长过程中发生的与年龄相关的组织形态计量学变化。在3周、4周、6周、8周、10周、13周和20周龄时从右肱骨采集样本进行光学显微镜检查。组织学研究表明,在3周龄时可以检测到远端生长板,而在4周龄时,它被骨小梁取代。从形态学上看,近端生长板的厚度存在差异,特别是其增殖区。增殖区的厚度最初减少,然后在青春期前后(6-8周)显著增加,然后从8-20周开始显著减少。研究期间,中轴皮质骨厚度显著增加。总之,衰老影响了大鼠肱骨的纵向和横向生长,这两者都参与了肱骨的生长和发育。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Age-related histomorphometrical changes of rat's humerus
Previous research divided long bone growth into intramembranous and endochondral ossification. The latter contributes to longitudinal bone growth through the addition of new bone tissue at the physeal growth plate. Bones, also, increase in thickness through appositional bone growth of the cortical bone. The aim of the present study was to investigate the age-related histomorphometrical changes that occur during the growth of the humerus in rats as a model of the long bone. Samples were collected for light microscopy from the right humerus at 3, 4, 6, 8, 10, 13, and 20 weeks (wks) of age. Histological investigation revealed that the distal physeal growth plate could be detected at 3 wks of age, while at 4 wks of age it was replaced by bone trabeculae. Morphometrically, differences were observed in the thickness of the proximal physeal growth plate, specifically its proliferative zone. The thickness of the proliferative zone initially decreased, then showed a significant increase around the age of puberty (6–8 wks), then decreased significantly from 8–20 wks of age. The mid-shaft cortical bone thickness showed a significant increase during the study. In conclusion, ageing affected both longitudinal and appositional growth, which both participated in the growth and development of the rat's humerus.
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