狭叶龙舌兰的植物化学筛选及其生物学潜力。叶提取物作为抗氧化剂和抗癌剂

IF 0.4 Q4 ONCOLOGY

Current Cancer Therapy Reviews Pub Date : 2022-08-26 DOI:10.2174/1573394718666220826153144

Priya Chikara, A. Deep, Nitin Bansal, Sanjiv Kumar, Sandeep Bansal, Arun Sharma, I. Singh, R. Marwaha

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引用次数: 0

摘要

龙舌兰。是一种商业作物，生长在瓦哈卡州（墨西哥南部）的高地，瓦哈卡是一个半干旱地区，属于龙舌兰科，它含有多种与各种生物活性有关的生物活性化合物。本研究的目的是评估龙舌兰提取物（AAE）的抗氧化和抗癌潜力。AAE含有酚类化合物、皂苷和脂肪酸，它们具有抗氧化和抗癌活性，根据GCMS分析，与标准药物（阿霉素）相比，AAE表现出基于过氧化氢清除测定的抗氧化活性（IC50值为203.00μg/ml）和抗癌活性（IC50值为82.70±1.458μg/ml），后者对HeLa CCL-2癌症细胞系的抑制率低于提取物。本研究测定了AAE的化学成分和生物学特性。

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Phytochemical screening and biological potentials of Agave angustifolia Haw. leaves extract as antioxidant and anticancer agents

Agave angustifolia Haw. is a commercial crop grown in the highlands of Oaxaca State (Southern Mexico), a semi-arid region that belongs to the Agavaceae family, and it contains a variety of bioactive compounds that are linked to various biological activities The purpose of this study was to assess the antioxidant and anticancer potential of Agave angustifolia extract (AAE). AAE contained phenolic compounds, saponins, and fatty acids, which are responsible for antioxidant and anticancer activity, according to the GCMS analysis AAE exhibited antioxidant activity based on Hydrogen peroxide scavenging assays (IC50 value of 203.00 µg/ml) and anticancer activity (IC50 value of 82.70±1.458 μg/ml) compared with standard drug (Doxorubicin) which shows lower inhibitory rate than Extract against HeLa CCL-2 cancer cell line. In this study, the chemical constituents and biological properties of AAE were determined.

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来源期刊

Current Cancer Therapy Reviews ONCOLOGY-

CiteScore

1.00

自引率

0.00%

发文量

期刊介绍： Current Cancer Therapy Reviews publishes frontier reviews on all the latest advances in clinical oncology, cancer therapy and pharmacology. The journal"s aim is to publish the highest quality review articles dedicated to clinical research in the field. The journal is essential reading for all researchers and clinicians in cancer therapy.