应用千伏锥束计算机断层扫描(CBCT)对前列腺癌患者直肠和膀胱的体积和剂量分析

Q4 Health Professions
K. Venkatesan, C. Raphael, K. Varghese, Paul G Gopu, S. Sivakumar, M. Boban, N. A. N. Raj, K. Senthilnathan, P. Babu
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引用次数: 0

摘要

背景:利用千伏“锥束计算机断层扫描”(CBCT)图像研究和分析前列腺癌患者直肠和膀胱给药剂量的变化。材料与方法:对7例前列腺癌症患者进行二维千伏(2D kV)成像和CBCT检查。将其偏移之间的偏差进行关联,并分析直肠和膀胱的体积变化。在每个升压分数上重新绘制直肠和膀胱轮廓,并在CBCT图像上进行剂量计算,以研究对剂量-体积直方图的影响。结果:CBCT软组织匹配和kV骨匹配之间的所有方向的设置变化的相关系数均在0.78以内。膀胱和直肠容积与升压分数的平均偏差分别为-12%至+9%(SD 31cc至70cc)和-10.2%至+12%(SD 3.1cc至14.9cc)。所有三个位置的膀胱平均剂量变化均<1.5Gy,而直肠的平均剂量变化<3.65Gy。膀胱与参考计划的D1%剂量偏差分别为1.1Gy(CBCT匹配位置)、1.4Gy(kV匹配位置)和1.7Gy(无校正),直肠的偏差分别为1.2Gy、2.2Gy和3.6Gy。在低剂量区域没有发现统计学意义上的显著偏差。结论:CBCT图像引导而不是kV骨匹配可以实现靶(前列腺)的良好剂量递送和一致性,但对直肠的剂量贡献取决于患者的解剖结构、膀胱充盈和直肠充盈,与检查日期有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Volume and dosimetric analysis of rectum and bladder for prostate carcinoma patients by using kilo voltage cone beam computed tomography (CBCT)
Background: To study and analyze the variations in delivered doses to rectum and bladder of carcinoma prostate patients by using kilo Voltage (kV) ‘Cone Beam Computed Tomography’ (CBCT) images. Materials and Methods: 2-Dimensional kilo Voltage (2D kV) Imaging and CBCT were done for seven prostate cancer patients. The deviations among their shifts were correlated and the volumetric changes of the rectum and bladder were analyzed. Rectum and bladder contours were redrawn on every boost fractions and dose calculation were performed on CBCT images to study the effect on dose volume histograms. Results: A correlation coefficient for set-up variations was within 0.78 for all directions between CBCT soft tissue matching and kV bone match. The mean deviation of bladder and rectum volume over the boost fractions was -12% to +9% (SD 31cc to 70cc) and -10.2% to+12% (SD 3.1cc to14.9cc), respectively. Bladder mean dose variation was <1.5Gy for all three positions whereas it was <3.65Gy for rectum. D1% dose deviation from reference plan for bladder was 1.1Gy (CBCT matched position), 1.4Gy (kV matched position), and 1.7Gy (no correction), and for rectum, the deviations were 1.2Gy, 2.2Gy, 3.6Gy, respectively. No significant deviation was found statistically significant at the low dose region. Conclusion: It is possible to achieve good dose delivery and conformity in target (prostate) with CBCT image guidance rather than kV bone match, but dose contribution to the rectum is dependent on the patient’s anatomy, bladder filling, and rectum filling, pertaining to the day of examination.
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来源期刊
Iranian Journal of Radiation Research
Iranian Journal of Radiation Research RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-
CiteScore
0.67
自引率
0.00%
发文量
0
审稿时长
>12 weeks
期刊介绍: Iranian Journal of Radiation Research (IJRR) publishes original scientific research and clinical investigations related to radiation oncology, radiation biology, and Medical and health physics. The clinical studies submitted for publication include experimental studies of combined modality treatment, especially chemoradiotherapy approaches, and relevant innovations in hyperthermia, brachytherapy, high LET irradiation, nuclear medicine, dosimetry, tumor imaging, radiation treatment planning, radiosensitizers, and radioprotectors. All manuscripts must pass stringent peer-review and only papers that are rated of high scientific quality are accepted.
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