具有骨组织工程应用前景的新型壳聚糖-碳酸盐羟基磷灰石复合材料的合成-理化分析

IF 0.8 Q4 MATERIALS SCIENCE, BIOMATERIALS

Progress on Chemistry and Application of Chitin and its Derivatives Pub Date : 2022-09-30 DOI:10.15259/pcacd.27.017

Justyna Urbaniak, Barbara Kołodziejska, A. Kaflak

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引用次数: 1

摘要

本研究的主题是合成12种壳聚糖-羟基磷灰石（CH:HA）复合材料，其具有不同含量的碳酸根离子（CO3-），两种重量比的CH/HA（30:70和50:50），以及两种粘度的CH（低[L]和高[H]）。采用引入试剂的直接共沉淀法。通过傅立叶变换红外光谱、粉末X射线衍射和扫描电子显微镜对所获得的材料的结构进行了表征。FT-IR光谱揭示了CH和HA的特征谱带的谱带和范围。通过红外光谱鉴定了CO3 2-引入到所获得的复合材料结构中的存在。在所获得的CH:HA生物复合材料中，在掺入的CO3-含量较高的材料中，观察到HA单位细胞的尺寸减小。所获得的纳米材料与天然骨组织相似。未来的研究将集中在对所获得的材料作为药物递送系统的评估上。

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SYNTHESIS OF NEW CHITOSAN-CARBONATE HYDROXYAPATITE COMPOSITES WITH POTENTIAL APPLICATION IN BONE TISSUE ENGINEERING – PHYSICOCHEMICAL ANALYSIS

The subject of this study was the synthesis of 12 chitosan-hydroxyapatite (CH:HA) composites with different contents of carbonate ions (CO3 2-), in two weight ratios of CH to HA (30:70 and 50:50), and two viscosities of CH (low [L] and high [H]). The method of direct co-precipitation of the introduced reagents was used. The structure of the obtained materials was characterised by Fourier-transform infrared (FT-IR) spectroscopy, powder X-ray diffraction, and scanning electron microscopy. The FT-IR spectra revealed the bands and ranges of the characteristic bands for CH and HA. The presence of CO3 2- introduced into the structure of the obtained composites was identified by infrared spectroscopy. A reduction in the size of HA unit cells was observed in the obtained CH:HA biocomposites, in materials with a higher content of incorporated CO3 2-. The obtained nanomaterials are similar to natural bone tissue. Future research will focus on the evaluation of the obtained materials as a drug delivery system.

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来源期刊

Progress on Chemistry and Application of Chitin and its Derivatives MATERIALS SCIENCE, BIOMATERIALS-

CiteScore

1.10

自引率

16.70%

发文量

期刊介绍： Progress in the Chemistry and Application of Chitin and its Derivatives is an annual journal focused on all aspects of production, modification, enzymology and application of chitin and its many derivatives, including chitosan. The journal publishes full-length papers as well as invited reviews. To be considered, papers must present original research that has not been published or accepted for publication elsewhere. The language of the journal will be English.