离子液体负载有机催化剂催化α-氰基α-磺酰基碳阴离子的不对称Mannich型反应

IF 0.9 Q4 CHEMISTRY, PHYSICAL

Current Organocatalysis Pub Date : 2023-05-16 DOI:10.2174/2213337210666230516145640

V. Srivastava

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引用次数: 0

摘要

合成了脯氨酸功能化离子液体，并用分析技术对其进行了进一步表征。在获得上述离子液体的适当结构信息后，我们利用它们作为不对称曼尼希反应的催化剂，以不同亚胺和芳基磺基的不同组合作为亲核试剂，合成了6种不同类型的β-氨基α-氰基砜衍生物作为曼尼希加合物。我们得到了相应的手性曼尼希加合物，然后进行简单的醚洗涤，收率和立体选择性都很好。我们在不损失催化活性的情况下循环使用了6次催化剂。

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Ionic Liquid Supported Organocatalysts for the Asymmetric Mannich-Type Reaction of α-cyano α-sulfonyl carbanions

We synthesized proline functionalized ionic liquid and further characterized it with analytical techniques. After getting proper structural information on the above ionic liquid, we utilized them as a catalyst for the asymmetric Mannich-Type Reaction We synthesized 6 different types of β-amino α-cyano sulfones derivatives as Mannich adduct using various combinations of different imines and aryl sulphonyl as pre-nucleophiles. We obtained the corresponding chiral Mannich adduct followed by simple ether washing in excellent yield and stereoselectivity. We recycled the catalyst up to 6 runs without losing the catalytic activity.

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来源期刊

Current Organocatalysis CHEMISTRY, PHYSICAL-

CiteScore

2.00

自引率

0.00%

发文量

期刊介绍： Current Organocatalysis is an international peer-reviewed journal that publishes significant research in all areas of organocatalysis. The journal covers organo homogeneous/heterogeneous catalysis, innovative mechanistic studies and kinetics of organocatalytic processes focusing on practical, theoretical and computational aspects. It also includes potential applications of organocatalysts in the fields of drug discovery, synthesis of novel molecules, synthetic method development, green chemistry and chemoenzymatic reactions. This journal also accepts papers on methods, reagents, and mechanism of a synthetic process and technology pertaining to chemistry. Moreover, this journal features full-length/mini review articles within organocatalysis and synthetic chemistry. It is the premier source of organocatalysis and synthetic methods related information for chemists, biologists and engineers pursuing research in industry and academia.