基于crispr激活的筛选揭示了在直接重编程过程中多梳抑制复合体2对神经元命运的促进作用。

Q1 Biochemistry, Genetics and Molecular Biology

Stem cell investigation Pub Date : 2019-09-12 DOI:10.21037/sci.2019.08.04

Tim Wolfram, B. Tursun

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引用次数: 0

摘要

通过重编程将一种细胞类型转化为另一种细胞类型，为疾病建模和再生医学提供了宝贵的机会。在一个备受期待的场景中，由重新编程的细胞产生的组织将被用来取代患有损伤或阿尔茨海默氏症等疾病的患者退化或丢失的组织，阿尔茨海默氏症会导致大脑中功能性神经细胞(神经元)的丧失。

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CRISPR-activation-based screen reveals neuronal fate promotion by polycomb repressive complex 2 during direct reprogramming.

Conversion of one cell type to another by reprogramming offers valuable opportunities for disease modeling and regenerative medicine. In a much-anticipated scenario, tissues generated from reprogrammed cells will be used to replace degenerated or lost tissues in patients suffering from injury or diseases such as Alzheimer’s, which causes loss of functional nerve cells (neurons) in the brain.

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来源期刊

Stem cell investigation Biochemistry, Genetics and Molecular Biology-Developmental Biology

CiteScore

5.80

自引率

0.00%

发文量

期刊介绍： The Stem Cell Investigation (SCI; Stem Cell Investig; Online ISSN: 2313-0792) is a free access, peer-reviewed online journal covering basic, translational, and clinical research on all aspects of stem cells. It publishes original research articles and reviews on embryonic stem cells, induced pluripotent stem cells, adult tissue-specific stem/progenitor cells, cancer stem like cells, stem cell niche, stem cell technology, stem cell based drug discovery, and regenerative medicine. Stem Cell Investigation is indexed in PubMed/PMC since April, 2016.