5-羟色胺3受体拮抗剂减轻丙泊酚注射疼痛、术后恶心/呕吐和颤抖的临床疗效：荟萃分析

IF 0.5 4区医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Pteridines Pub Date : 2020-01-01 DOI:10.1515/pteridines-2020-0003

Wenjie Zhou, Jie Zhou

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The publication bias was assessed by funnel plot and Egger’s line regression test. Results After screening, a total of 19 publications relevant to 5-HT3 receptor antagonists in reducing propofol injection pain and prevention of postoperative nausea/vomiting or shivering were included for analysis. The pooled results demonstrated that 5-HT3 receptor antagonists could significantly reduce the total propofol injection pain compared to placebo (RR=0.49, 95%CI:0.45-0.54, P<0.05). For mild propofol injection pain, there was no statistical difference between 5-HT3 receptor antagonists and control groups (RR=1.07,95%CI:0.89-1.29, P>0.05). However, for moderate (RR=0.37, 95%CI: 0.31-0.46, P<0.05) and severe (RR=0.19, 95%CI:0.14-0.27, P<0.05) propofol injection pain, the incidence in 5-HT3 receptor antagonists was significantly lower than that of control groups. 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引用次数: 0

摘要

摘要目的通过收集已发表的资料，探讨5-羟色胺3（5-HT3）受体拮抗剂减轻丙泊酚注射疼痛、术后恶心/呕吐和颤抖的临床疗效。方法从Pubmed、Cochrane对照试验中心注册库、EMBASE和万方四个电子数据库中确定2019年6月前发表的5-HT3受体拮抗剂减轻丙泊酚注射疼痛的前瞻性随机临床研究。通过随机或固定效应模型汇集个体数据，将5-HT3受体拮抗剂后患者的丙泊酚注射疼痛、术后恶心/呕吐和颤抖的发生率与相关对照组进行比较。通过漏斗图和Egger线性回归检验评估发表偏倚。结果筛选后，共纳入19篇与5-HT3受体拮抗剂减轻丙泊酚注射疼痛和预防术后恶心/呕吐或颤抖有关的出版物进行分析。结果表明，与安慰剂相比，5-HT3受体拮抗剂可显著减轻丙泊酚总注射疼痛（RR=0.49，95%CI:0.45-0.54，P0.05）。但对于中度（RR=0.37，95%CI:0.31-0.46，P<0.05）和重度（RR=0.19，95%CI:0.14-0.27，P<0.05）丙泊酚注射疼痛，5-HT3受体拮抗剂的发生率显著低于对照组。合并结果还表明，与对照组相比，5-HT3受体拮抗剂组的术后恶心/呕吐（RR=0.28，95%CI:0.17-0.44，P<0.05）和术后颤抖（RR=0.33，95%CI:0.23-0.48，P<0.05）的发生率显著降低，具有统计学差异。结论：在这项荟萃分析中，5-HT3受体拮抗剂有效地减轻了丙泊酚注射疼痛、术后恶心/呕吐和颤抖。

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Clinical efficacy of 5-hydroxytryptamine 3 receptor antagonists in reducing propofol injection pain, postoperative nausea/vomiting and shivering: A meta-analysis

Abstract Objective To investigate the clinical efficacy of 5-hydroxytryptamine 3 (5-HT3) receptor antagonists in reducing propofol injection pain, postoperative nausea/ vomiting, and shivering through pooling the available published data. Methods Prospective randomized clinical studies relevant to 5-HT3 receptor antagonists in reducing propofol injection pain published before June 2019 were identified from four electronic databases, Pubmed, the Cochrane central register of controlled trials, EMBASE and Wanfang. The incidence of propofol injection pain, postoperative nausea/vomiting, and shivering in patients after 5-HT3 receptor antagonists were compared to relevant control groups by pooling the individual data through random or fixed-effect models. The publication bias was assessed by funnel plot and Egger’s line regression test. Results After screening, a total of 19 publications relevant to 5-HT3 receptor antagonists in reducing propofol injection pain and prevention of postoperative nausea/vomiting or shivering were included for analysis. The pooled results demonstrated that 5-HT3 receptor antagonists could significantly reduce the total propofol injection pain compared to placebo (RR=0.49, 95%CI:0.45-0.54, P<0.05). For mild propofol injection pain, there was no statistical difference between 5-HT3 receptor antagonists and control groups (RR=1.07,95%CI:0.89-1.29, P>0.05). However, for moderate (RR=0.37, 95%CI: 0.31-0.46, P<0.05) and severe (RR=0.19, 95%CI:0.14-0.27, P<0.05) propofol injection pain, the incidence in 5-HT3 receptor antagonists was significantly lower than that of control groups. The pooled results also indicated that incidence of postoperative nausea/vomiting (RR=0.28, 95%CI:0.17-0.44, P<0.05) and postoperative shivering (RR=0.33, 95%CI:0.23-0.48, P<0.05) were significantly reduced in 5-HT3 receptor antagonists group compared to control group with a statistical difference. Conclusion: In this meta-analysis, 5-HT3 receptor antagonists effectively reduced propofol injection pain, postoperative nausea/vomiting, and shivering.

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来源期刊

Pteridines 生物-生化与分子生物学

CiteScore

1.20

自引率

25.00%

发文量

审稿时长

>12 weeks

期刊介绍： Pteridines is an open acess international quarterly journal dealing with all aspects of pteridine research. Pteridines are heterocyclic fused ring compounds involved in a wide range of biological functions from the color on butterfly wings to cofactors in enzyme catalysis to essential vitamins. Of the pteridines, 5,6,7,8-tetrahydrobiopterin is the necessary cofactor of several aromatic amino acid monoxygenases, the nitric oxide synthases and glyceryl ether monoxygenase (GEMO). Neopterin plays an essential role in the immune system and is an important biomarker in laboratory medicine for diseases such as HIV, cardiovascular disease, malignant tumors, among others. Topics: -Neopterin, dihydroneopterin, monapterin- Biopterin, tetrahydrobiopterin- Folates, antifolates, riboflavin- Phenylalanine, tyrosine, phenylketonuria, serotonin, adrenalin, noradrenalin, L-DOPA, dopamine, related biogenic amines- Phenylalanine hydroxylase, tyrosine hydroxylase, tryptophan hydroxylase, nitric oxide synthases (iNOS), alkylglycerol monooxygenase (AGMO), dihydropterin reductase, sepiapterin reductase- Homocysteine, mediators of inflammation, redox systems, iron.