木犀草挥发油的植物化学成分及抗氧化抗炎活性卡斯。生长在印度北部的北阿坎德邦的Terai地区

IF 1.6 Q3 URBAN STUDIES

TOWN PLANNING REVIEW Pub Date : 2021-03-01 DOI:10.30495/TPR.2021.680495

K. Gairola, Shriya Gururani, Ravendra Kumar, O. Prakash, S. Agarwal, S. Dubey

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引用次数: 1

摘要

植物Acmella uliginosa（Sw.）Cass。对菊科植物进行了加氢蒸馏提取精油，并用GC/MS对其植物化学成分进行了化学分析。鉴定出35种化合物，占精油总成分的88.1%。柠檬烯（12.2%）、倍半沙宾烯异构体（7.3%）和氧化石竹烯（5.9%）是该精油的主要化合物。通过DPPH自由基清除活性和金属螯合活性研究了精油的体外抗氧化活性，IC50值分别为326.77±5.34μL和14.853±0.106μL，而还原力活性为14.011±0.0446μL。与IB50值为23.693±0.306μg/mL的标准双氯芬酸钠盐相比，精油表现出强大的抗炎活性，IB50值是5.629±0.0311μL。与标准上市药物相比，这种精油表现出极其显著的抗炎和抗氧化活性。

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Phytochemical composition, antioxidant, and anti-inflammatory activities of essential oil of Acmella uliginosa (Sw.) Cass. grown in North India Terai region of Uttarakhand

The plant Acmella uliginosa (Sw.) Cass. belonging to family Asteraceae was subjected to hydro distillation for essential oil extraction and was chemically analyzed by GC/MS for its phytochemical composition. Thirty-five compounds were identified comprising 88.1% of total essential oil composition. Limonene (12.2%) along with sesquisabinene isomer (7.3%) and caryophyllene oxide (5.9%) were the prominent compounds of the essential oil. In-vitro antioxidant activity of essential oil was investigated by DPPH free radical scavenging activity and metal chelating activity having IC50 value of 326.77 ± 5.34 μL and 14.853 ± 0.106 μL respectively whereas reducing power activity having RP50 value of 14.011 ± 0.0446 μL. The essential oil exhibited potent anti-inflammatory activity with IB50 value of 5.629 ± 0.0311 μL compared to standard Diclofenac sodium salt having IB50 value of 23.693 ± 0.306 μg/mL. The essential oil displayed exceedingly marked anti-inflammatory as well as antioxidant activities as compared to standard marketed drugs.

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来源期刊

TOWN PLANNING REVIEW URBAN STUDIES-

CiteScore

3.40

自引率

0.00%

发文量

期刊介绍： Town Planning Review has been one of the world"s leading journals of urban and regional planning since its foundation in 1910. With an extensive international readership, TPR is a well established urban and regional planning journal, providing a principal forum for communication between researchers and students, policy analysts and practitioners. To mark TPR’s centenary in 2010, it is proposed to publish a series of ‘Centenary Papers’ -- review papers that record and reflect on the state of the art in a range of topics in the general field of town and regional planning.