结节性瘙痒症的免疫靶点及治疗

IF 6.2 Q1 IMMUNOLOGY
A. Labib, T. Ju, A. Vander Does, G. Yosipovitch
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引用次数: 10

摘要

结节性痒疹是一种慢性炎症性皮肤病,由严重瘙痒性结节组成,可使患者非常虚弱。这种皮肤状况的基础是免疫失调和神经放大,由t淋巴细胞、肥大细胞、嗜酸性粒细胞、巨噬细胞和介导瘙痒过程的细胞因子驱动。由于缺乏经批准的治疗方法和管理上的共识,使这一本已繁重的诊断变得更加复杂;尽管有一些标签外的治疗方法被用作治疗。免疫调节剂是PN治疗的基石,目前正在研究针对免疫级联关键参与者的其他新疗法。在这篇综述中,我们将重点介绍免疫级联的靶点,并探讨目前的免疫调节治疗方法以及未来治疗结节性痒疹的免疫疗法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Immunotargets and Therapy for Prurigo Nodularis
Abstract Prurigo nodularis is a chronic inflammatory skin disease consisting of severely pruritic nodules that can be very debilitating for patients. The basis of this skin condition is immunological dysregulation and neural amplification, driven by T-lymphocytes, mast cells, eosinophilic granulocytes, macrophages, and cytokines mediating itchy processes. Further complicating this already taxing diagnosis is the lack of approved treatment and consensus on management; although there are off-label treatments utilized as therapy. Immunomodulators are the cornerstone of treatment for PN, and additional novel therapies targeting key players in the immunological cascade are currently undergoing investigation. In this review, we will highlight targets of the immune cascade and explore current immunomodulating treatments as well as immunotherapies on the horizon for the management of prurigo nodularis.
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来源期刊
CiteScore
16.50
自引率
0.00%
发文量
7
审稿时长
16 weeks
期刊介绍: Immuno Targets and Therapy is an international, peer-reviewed open access journal focusing on the immunological basis of diseases, potential targets for immune based therapy and treatment protocols employed to improve patient management. Basic immunology and physiology of the immune system in health, and disease will be also covered.In addition, the journal will focus on the impact of management programs and new therapeutic agents and protocols on patient perspectives such as quality of life, adherence and satisfaction.
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