探索病原体在人类肠道微生物群中的结合潜力

Q1 Medicine

Human Microbiome Journal Pub Date : 2020-12-01 DOI:10.1016/j.humic.2020.100075

Kawe Toutounian , Marie Luise Heinig , Peter Götz , Philippe Ulsemer

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引用次数: 1

摘要

细菌性肠胃炎的感染过程往往依赖于毒素与宿主细胞上碳水化合物受体的初始结合。我们筛选了人类肠道微生物群，寻找天然表达毒素结合碳水化合物结构的微生物。从四名健康成年捐赠者的粪便样本中，我们分离出特异性结合霍乱毒素和热不稳定毒素的细菌菌株。这些结果表明了一种新的机制，通过这种机制，微生物组可能会影响人们对胃肠道感染的个体敏感性。这项研究也可能为开发基于非抗生素微生物组的策略来治疗和预防胃肠道感染铺平道路。

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Exploring the pathogen binding potential within the human gut microbiome

The infection process of bacterial gastroenteritis often relies on the initial binding of toxins to carbohydrate receptors on host cells. We screened the human gut microbiota for microorganisms naturally expressing toxin-binding carbohydrate structures. Out of stool samples from four healthy adult donors, we isolated bacterial strains specifically binding the cholera toxin and the heat labile toxin. These results suggest a new mechanism by which the microbiome may shape people’s individual sensitivity to gastrointestinal infections. This study may also pave the way for the development of non-antibiotic microbiome based strategies to treat and prevent gastrointestinal infections.

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来源期刊

Human Microbiome Journal Medicine-Infectious Diseases

自引率

0.00%

发文量

期刊介绍： The innumerable microbes living in and on our bodies are known to affect human wellbeing, but our knowledge of their role is still at the very early stages of understanding. Human Microbiome is a new open access journal dedicated to research on the impact of the microbiome on human health and disease. The journal will publish original research, reviews, comments, human microbe descriptions and genome, and letters. Topics covered will include: the repertoire of human-associated microbes, therapeutic intervention, pathophysiology, experimental models, physiological, geographical, and pathological changes, and technical reports; genomic, metabolomic, transcriptomic, and culturomic approaches are welcome.