天然产物调节离子通道治疗心房颤动的研究进展

IF 3.4 4区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Cardiovascular Therapeutics Pub Date : 2022-03-22 DOI:10.1155/2022/4559809

Jinshan He, Sicong Li, Yumeng Ding, Yujia Tong, Xuebin Li

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引用次数: 6

摘要

抗心律失常药物（AADs）通过调节离子通道的功能对心房颤动（AF）具有治疗作用。然而，停药后的一些不良反应和高复发率严重影响了患者的用药依从性和临床预后。因此，迫切需要更安全、更有效的药物。从天然产品中提取的活性成分是AF治疗的潜在选择。天然产品如三七（Burk.）F.H.Chen、苦参、。，Stephania tetrandra S.Moore。，葛根。，和黄连。在中国治疗心律失常、心肌梗死、中风和心力衰竭有着悠久的历史。根据化学结构的分类，探讨了天然产物成分通过调节离子通道、连接蛋白和相关基因表达对心房颤动的治疗作用，为开发心房颤动治疗药物提供参考。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Research Progress on Natural Products' Therapeutic Effects on Atrial Fibrillation by Regulating Ion Channels

Antiarrhythmic drugs (AADs) have a therapeutic effect on atrial fibrillation (AF) by regulating the function of ion channels. However, several adverse effects and high recurrence rates after drug withdrawal seriously affect patients' medication compliance and clinical prognosis. Thus, safer and more effective drugs are urgently needed. Active components extracted from natural products are potential choices for AF therapy. Natural products like Panax notoginseng (Burk.) F.H. Chen, Sophora flavescens Ait., Stephania tetrandra S. Moore., Pueraria lobata (Willd.) Ohwi var. thomsonii (Benth.) Vaniot der Maesen., and Coptis chinensis Franch. have a long history in the treatment of arrhythmia, myocardial infarction, stroke, and heart failure in China. Based on the classification of chemical structures, this article discussed the natural product components' therapeutic effects on atrial fibrillation by regulating ion channels, connexins, and expression of related genes, in order to provide a reference for development of therapeutic drugs for atrial fibrillation.

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来源期刊

Cardiovascular Therapeutics 医学-心血管系统

CiteScore

5.60

自引率

0.00%

发文量

审稿时长

6 months

期刊介绍： Cardiovascular Therapeutics (formerly Cardiovascular Drug Reviews) is a peer-reviewed, Open Access journal that publishes original research and review articles focusing on cardiovascular and clinical pharmacology, as well as clinical trials of new cardiovascular therapies. Articles on translational research, pharmacogenomics and personalized medicine, device, gene and cell therapies, and pharmacoepidemiology are also encouraged. Subject areas include (but are by no means limited to): Acute coronary syndrome Arrhythmias Atherosclerosis Basic cardiac electrophysiology Cardiac catheterization Cardiac remodeling Coagulation and thrombosis Diabetic cardiovascular disease Heart failure (systolic HF, HFrEF, diastolic HF, HFpEF) Hyperlipidemia Hypertension Ischemic heart disease Vascular biology Ventricular assist devices Molecular cardio-biology Myocardial regeneration Lipoprotein metabolism Radial artery access Percutaneous coronary intervention Transcatheter aortic and mitral valve replacement.