用蒙特卡罗模拟研究金纳米粒子对乳腺癌患者辐射剂量分布的影响

Pub Date : 2020-10-01 DOI:10.15251/jobm.2020.124.101

H. Bush, M. H. Eisa, A. Ramizy, M. Ashari, Kh. M. Haroun, O. Aldaghri, M. D. Abd-Alla

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引用次数: 0

摘要

利用MCNP5代码的模拟模型研究了金纳米颗粒(AuNPs)在乳腺癌样本中的作用。使用MCNP5代码计算水中和乳腺幻影中AuNPs的剂量率分布。对于不均匀性，设计锥细胞计算Ir-192在乳腺和含有不同浓度金纳米颗粒的非均匀介质中的剂量分布。采用轨迹长度能量沉积计数(F6)和脉冲高度计数(*F8)两种气压计。结果表明，F6比*F8更适合于辐射剂量的计算。在平均角度为5˚和175˚的情况下，与已发表的计数F6和*F8在水中的角剂量分布进行了比较，计数F6的百分比范围为0.0136 ~ 0.3019%。*F8计数在平均角度为75˚和5˚时的百分比范围为- 0.0014 ~ 0.8253 %。对于乳房幻像，比较F6计数和*F8计数的结果。在平均角度为15˚和175˚时，两种计算结果在角度各向异性分布上的差异在0.0514 ~ 0.4596%之间。结果表明，浓度增加到10% (100mg /ml)时，AuNP剂量增加，浓度大于10%时，剂量减小。不推荐超过10%的aunp浓度。结果表明，F6计数是计算乳腺癌不均匀性对近距离放疗影响的良好工具。

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THE EFFECT OF GOLD NANOPARTICLES ON RADIATION DOSE DISTRIBUTION IN BREAST CANCER USING MONTE CARLO SIMULATION

The simulation model for MCNP5 code was used to study the effect of the gold nanoparticle (AuNPs) in cancer breast samples. The dose rate distribution of AuNPs in water and breast phantom was calculated using MCNP5 code. For inhomogeneities, cone cells were designed to calculate dose distribution around Ir-192 source in breast and inhomogeneous medium that includes gold nanoparticles at different concentration. Both barometers, the track length energy deposition tally (F6) and pulse height tally (*F8), were used. The result indicated that the F6 is better than *F8 for radiation dose calculation. Angular doses distribution in water was compared with data published for tally F6 and*F8 with the different percentage range of 0.0136 to 0.3019% for tally F6 at the average angle of 5˚and 175˚respectively. For *F8 tally, different percentage range of - 0.0014 to 0.8253 % was obtained at an average angle of 75˚and 5˚ respectively. For breast phantom, the result of the F6 tally with the *F8 tally was compared. The difference in calculations between the two tallies in the angular anisotropic distribution was found to be in the range from 0.0514 to 0.4596% at the average angle of 15 ˚ and 175 ˚ respectively. The obtained results showed that the AuNP dose increases when the concentration increases up to ten percent (100 mg/ml), and then decreases for concentration higher than ten percent. The concentration of AuNPs greater than ten percent is not recommended. The results indicated that tally F6 is a good tool to calculate the effect of inhomogeneities due to breast cancer on brachytherapy.

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