补充维生素B12、B6和叶酸对南非低收入、城市化黑人老年社区同型半胱氨酸代谢的影响

IF 0.8 Q4 NUTRITION & DIETETICS
CJ Grobler, W. Oldewage-Theron, J. Chalwe
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引用次数: 1

摘要

目的:本研究的目的是评估维生素B12、B6和叶酸补充剂在100%推荐膳食摄入量(RDA)下补充6个月对南非老年城市化黑人社区血清同型半胱氨酸(Hcy)水平的影响。设计:在104个有目的选择的样本中采用实验性、非等效对照组干预研究设计。比较两组:高同型半胱氨酸血症(hyperHcy) (n = 61)和正常半胱氨酸血症(normmohcy) (n = 43)。环境:南非豪登省沙佩维尔一家日托中心的老人。受试者:所有受试者在年龄(50 - 60岁)、种族(黑人)和失业/领取养老金者方面相同。结果测量:在基线和补充六个月后确定以下参数:血清Hcy,维生素B6, B12和叶酸水平,红细胞计数,平均细胞体积,血红蛋白,红细胞压积和维生素B6, B12和叶酸的营养摄入量。结果:高同型半胱氨酸血症发生率极高(66.36%)。干预后高同型半胱氨酸血症患者血清Hcy均值±标准差(SD)由25.00±8.00 umol/l降至18.80±12.00 umol/l,具有统计学意义。干预后,Hcy水平升高的应答者人数从100%(基线)下降到67%。结论:补充维生素B6、B12和叶酸是降低老年人高同型半胱氨酸血症的有效途径,从而降低其心血管疾病(CVD)的风险。补充维生素B6对应答者的血清维生素B6以及他们的造血(减少巨噬细胞)有有益的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The effect of vitamins B12, B6 and folate supplementation on homocysteine metabolism in a low-income, urbanised, black elderly community in South Africa
Objectives: The aim of this study was to assess the effect of vitamins B12, B6 and folate supplementation at >100% Recommended Dietary Allowances (RDA) for six months on serum homocysteine (Hcy) levels of an elderly urbanised black South African community. Design: An experimental, non-equivalent control group intervention study design was used in a 104 purposively selected sample. Two groups were compared: hyperhomocysteinaemic (hyperHcy) (n = 61) and normo-homocysteinaemic (normoHcy) (n = 43). Setting: Elders attending a day-care centre in Sharpeville, Gauteng, South Africa. Subjects: All subjects were equivalent in age (> 60 years), race (black) and unemployed/pensioner. Outcome measures: The following parameters were determined at baseline and after the six-month supplementation: serum Hcy, vitamins B6, B12 and folate levels, red cell count, mean cell volume, haemoglobin, haematocrit and the nutritional intake of vitamin B6, B12 and folate. Results: A very high incidence (66.36%) of hyperhomocysteinaemia was present in the sample. The mean ± standard deviation (SD) serum Hcy level in hyperhomocysteinaemic individuals decreased statistically significantly from 25.00 ± 8.00 umol/l to 18.80 ± 12.00 umol/l after the intervention. The number of respondents with an increased Hcy level decreased from 100% (baseline) to 67% after the intervention. Conclusions: It is concluded that supplementation of vitamins B6, B12 and folate is an effective Hcy-lowering approach to reduce hyperhomocysteinaemia in an elderly population, and thereby reduce their risk of cardiovascular disease (CVD). Summary The supplementation had a beneficial effect on the respondents’ serum vitamin B6 as well as their haemopoiesis (decreased macrocytosis).
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来源期刊
CiteScore
2.50
自引率
9.10%
发文量
21
期刊介绍: 1.The Journal accepts articles from all basic and applied areas of dietetics and human nutrition, including clinical nutrition, community nutrition, food science, food policy, food service management, nutrition policy and public health nutrition. 2.The Journal has a broad interpretation of the field of nutrition and recognizes that there are many factors that determine nutritional status and that need to be the subject of scientific investigation and reported in the Journal. 3.The Journal seeks to serve a broad readership and to provide information that will be useful to the scientific community, the academic community, government and non-government stakeholders in the nutrition field, policy makers and industry.
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