{"title":"小rna和长链非编码rna调控线粒体对脑缺血再灌注损伤影响的研究进展","authors":"Yanan Tang, Qian Zhang, Gaofeng Zhang, Huai-long Chen, Xiao-peng Sun, Fei Shi","doi":"10.3760/CMA.J.ISSN.1673-4378.2020.01.024","DOIUrl":null,"url":null,"abstract":"Cerebral ischemia/reperfusion injury (CI/RI) is a common clinical pathophysiological phenomenon after thrombus recanalization in stroke patients. Its pathogenetic mechanism involves multiple steps, of which mitochondria play a key role as \"energy stations\". Cerebral ischemic stroke induces remarkable changes in the expression of microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) in the brain, which indicates the association of miRNAs and lncRNAs of the complex pathological process after ischemic stroke. In addition, some related miRNAs and lncRNAs are found to participate in the development of CI/RI by regulating mitochondria. The current review is designed to summarize the effects of mitochondria on CI/RI, and the latest research findings about the involvement of miRNAs and lncRNAs to regulate CI/RI, so as to provide new targets and ideas for the prevention and treatment of CI/RI, as well as new thoughts and ideas for the prevention and treatment of CI/RI. \n \n \nKey words: \nCerebral ischemia; Reperfusion injury; Mitochondria; MicroRNAs; Long non-coding RNAs","PeriodicalId":13847,"journal":{"name":"国际麻醉学与复苏杂志","volume":"41 1","pages":"111-115"},"PeriodicalIF":0.0000,"publicationDate":"2020-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Research progress in the effects of regulation of mitochondria by microRNAs and long non-coding RNAs on cerebral ischemia/reperfusion injury\",\"authors\":\"Yanan Tang, Qian Zhang, Gaofeng Zhang, Huai-long Chen, Xiao-peng Sun, Fei Shi\",\"doi\":\"10.3760/CMA.J.ISSN.1673-4378.2020.01.024\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Cerebral ischemia/reperfusion injury (CI/RI) is a common clinical pathophysiological phenomenon after thrombus recanalization in stroke patients. Its pathogenetic mechanism involves multiple steps, of which mitochondria play a key role as \\\"energy stations\\\". Cerebral ischemic stroke induces remarkable changes in the expression of microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) in the brain, which indicates the association of miRNAs and lncRNAs of the complex pathological process after ischemic stroke. In addition, some related miRNAs and lncRNAs are found to participate in the development of CI/RI by regulating mitochondria. The current review is designed to summarize the effects of mitochondria on CI/RI, and the latest research findings about the involvement of miRNAs and lncRNAs to regulate CI/RI, so as to provide new targets and ideas for the prevention and treatment of CI/RI, as well as new thoughts and ideas for the prevention and treatment of CI/RI. \\n \\n \\nKey words: \\nCerebral ischemia; Reperfusion injury; Mitochondria; MicroRNAs; Long non-coding RNAs\",\"PeriodicalId\":13847,\"journal\":{\"name\":\"国际麻醉学与复苏杂志\",\"volume\":\"41 1\",\"pages\":\"111-115\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2020-01-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"国际麻醉学与复苏杂志\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.3760/CMA.J.ISSN.1673-4378.2020.01.024\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"国际麻醉学与复苏杂志","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3760/CMA.J.ISSN.1673-4378.2020.01.024","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Research progress in the effects of regulation of mitochondria by microRNAs and long non-coding RNAs on cerebral ischemia/reperfusion injury
Cerebral ischemia/reperfusion injury (CI/RI) is a common clinical pathophysiological phenomenon after thrombus recanalization in stroke patients. Its pathogenetic mechanism involves multiple steps, of which mitochondria play a key role as "energy stations". Cerebral ischemic stroke induces remarkable changes in the expression of microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) in the brain, which indicates the association of miRNAs and lncRNAs of the complex pathological process after ischemic stroke. In addition, some related miRNAs and lncRNAs are found to participate in the development of CI/RI by regulating mitochondria. The current review is designed to summarize the effects of mitochondria on CI/RI, and the latest research findings about the involvement of miRNAs and lncRNAs to regulate CI/RI, so as to provide new targets and ideas for the prevention and treatment of CI/RI, as well as new thoughts and ideas for the prevention and treatment of CI/RI.
Key words:
Cerebral ischemia; Reperfusion injury; Mitochondria; MicroRNAs; Long non-coding RNAs
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
