{"title":"儿童罕见的抗M2抗体介导的自身免疫性脑脊髓炎病例","authors":"Han-Sol Kim, M. Yum, Min‐Jee Kim, T. Ko","doi":"10.26815/acn.2022.00150","DOIUrl":null,"url":null,"abstract":"A 9-year-old boy with no relevant previous medical history was admitted to our clinic following 9 days of persistent fever and headache, followed by generalized motor weakness and an altered state of mentality. The patient was initially evalu-ated by a primary care physician and treated with antibiotics, although no improvement was observed. On his first visit to our hospital, he displayed a confused mental state, signs of meninge-al irritation, and decreased motor power (grades I–II) in all extremities on neurologic examinations. Laboratory tests, including thyroid func-tion tests, level of immunoglobulin, and comple-ments, were unremarkable. Brain and spine magnetic resonance imaging (MRI) showed T2 flu-id-attenuated inversion recovery (FLAIR) high signal changes in the basal ganglia, thalami, cor-pus callosum, brainstem, cerebellum, and entire spinal cord with leptomeningeal enhancement (Fig. 1A).","PeriodicalId":33305,"journal":{"name":"Annals of Child Neurology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2022-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A Rare Case of Anti-Ma2 Antibody-Mediated Autoimmune Encephalomyelitis in Childhood\",\"authors\":\"Han-Sol Kim, M. Yum, Min‐Jee Kim, T. Ko\",\"doi\":\"10.26815/acn.2022.00150\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"A 9-year-old boy with no relevant previous medical history was admitted to our clinic following 9 days of persistent fever and headache, followed by generalized motor weakness and an altered state of mentality. The patient was initially evalu-ated by a primary care physician and treated with antibiotics, although no improvement was observed. On his first visit to our hospital, he displayed a confused mental state, signs of meninge-al irritation, and decreased motor power (grades I–II) in all extremities on neurologic examinations. Laboratory tests, including thyroid func-tion tests, level of immunoglobulin, and comple-ments, were unremarkable. Brain and spine magnetic resonance imaging (MRI) showed T2 flu-id-attenuated inversion recovery (FLAIR) high signal changes in the basal ganglia, thalami, cor-pus callosum, brainstem, cerebellum, and entire spinal cord with leptomeningeal enhancement (Fig. 1A).\",\"PeriodicalId\":33305,\"journal\":{\"name\":\"Annals of Child Neurology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-06-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Annals of Child Neurology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.26815/acn.2022.00150\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annals of Child Neurology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.26815/acn.2022.00150","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
A Rare Case of Anti-Ma2 Antibody-Mediated Autoimmune Encephalomyelitis in Childhood
A 9-year-old boy with no relevant previous medical history was admitted to our clinic following 9 days of persistent fever and headache, followed by generalized motor weakness and an altered state of mentality. The patient was initially evalu-ated by a primary care physician and treated with antibiotics, although no improvement was observed. On his first visit to our hospital, he displayed a confused mental state, signs of meninge-al irritation, and decreased motor power (grades I–II) in all extremities on neurologic examinations. Laboratory tests, including thyroid func-tion tests, level of immunoglobulin, and comple-ments, were unremarkable. Brain and spine magnetic resonance imaging (MRI) showed T2 flu-id-attenuated inversion recovery (FLAIR) high signal changes in the basal ganglia, thalami, cor-pus callosum, brainstem, cerebellum, and entire spinal cord with leptomeningeal enhancement (Fig. 1A).