亚洲人群中的Brugada综合征:最新进展

IF 0.5 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS
M. Khawaja, Y. K. Qadeer, Rehma Siddiqui, Mihail G. Chelu, Noppawit Aiumtrakul, J. Pickett, R. Brugada, J. Brugada, P. Brugada, C. Krittanawong
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引用次数: 0

摘要

Brugada综合征(BrS)是一种遗传性心脏通道病,表现力可变,可导致心脏骤停(SCA)。世界各地的研究表明,BrS和Brugada模式(BrP)的普遍发病率较低。然而,研究也指出,BrS在某些亚洲人群中最为普遍。在全球不同地区中,流行率最高的地区是东南亚,其次是中东、南亚、东亚、欧洲和北美。重要的是,不仅要认识到亚洲BrS患病率的不同程度,而且要了解在症状、潜在风险因素和对临床结果的影响方面可能存在显著差异。识别这些差异的重要性在于有必要制定改进的风险评估策略,以指导这些患者的二次预防和治疗。具体来说,决定植入植入式心脏除颤器(ICD)可以挽救高危BrS患者的生命。然而,对于如何最好地对BrS患者进行风险分层,仍然缺乏共识。虽然目前的指南建议在出现晕厥的自发性1型心电图BrS患者中植入ICD,但在恶性心律失常发生之前,可能仍存在其他临床因素,这些因素可以作为更好的预测因素或促进更精细的风险分层。鉴于BrS患者在SCA之前通常没有任何先前症状,这具有巨大的相关性。这篇综述旨在描述亚洲大陆BrS表现和患病率的差异,以期确定潜在的风险因素,指导未来更好地预测和管理BrS患者。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Brugada Syndrome within Asian Populations: State-of-the-Art Review
Brugada syndrome (BrS) is an inherited cardiac channelopathy with variable expressivity that can lead to sudden cardiac arrest (SCA). Studies worldwide suggest that BrS and Brugada pattern (BrP) have low prevalences in general. However, studies also note that BrS is most prevalent among certain Asian populations. Among the different global regions, the highest prevalence is believed to be in Southeast Asia, followed by the Middle East, South Asia, East Asia, Europe, and North America. It is not only important to recognize such varying degrees of BrS prevalence within Asia but also to understand that there may be significant differences in terms of presenting symptoms, occult risk factors, and the impact on clinical outcomes. The importance of identifying such differences lies in the necessity to develop improved risk assessment strategies to guide secondary prevention and treatment for these patients. Specifically, the decision to pursue placement of an implantable cardiac defibrillator (ICD) can be lifesaving for high-risk BrS patients. However, there remains a significant lack of consensus on how to best risk stratify BrS patients. While the current guidelines recommend ICD implantation in patients with spontaneous Type 1 ECG pattern BrS who present with syncope, there may still exist additional clinical factors that may serve as better predictors or facilitate more refined risk stratification before malignant arrhythmias occur. This carries huge relevance given that BrS patients often do not have any preceding symptoms prior to SCA. This review seeks to delineate the differences in BrS presentation and prevalence within the Asian continent in the hope of identifying potential risk factors to guide better prognostication and management of BrS patients in the future.
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来源期刊
Cardiogenetics
Cardiogenetics CARDIAC & CARDIOVASCULAR SYSTEMS-
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26
审稿时长
11 weeks
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