2,3-二氢喹唑啉-4(1H)- 1作为Hg2+离子荧光传感器及其在肿瘤治疗中的对接研究

IF 0.7 Q3 MULTIDISCIPLINARY SCIENCES

Chemistry-Didactics-Ecology-Metrology Pub Date : 2022-12-01 DOI:10.2478/cdem-2022-0004

Ghodsi Mohammadi Ziarani, Shadi Tahmasebi Ashtiani, Fatemeh Mohajer, A. Badiei, S. Gaikwad, R. Varma

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引用次数: 1

摘要

摘要采用SBA-Pr-SO3H展开法制备了2,3-二氢喹唑啉-4(1H)- 1，并对其作为高选择性Hg2+离子荧光传感器的应用进行了探索;Hg2+离子选择性降低荧光强度。此外，该化合物对其他离子具有良好的抗干扰能力。值得一提的是，这种化合物可以用来检测极少量的Hg2+离子，这是一种剧毒的普通污染物。对接研究表明，分子2,3-二氢喹唑啉-4(1H)- 1是一种很好的5ACC酶抑制剂。

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2,3-Dihydro-Quinazolin-4(1H)-One as a Fluorescent Sensor for Hg2+ Ion and its Docking Studies in Cancer Treatment

Abstract The 2,3-dihydro-quinazolin-4(1H)-one was synthesised via the deployment of SBA-Pr-SO3H and its application was explored as a highly selective fluorescent sensor for Hg2+ ion; fluorescence intensity was decreased selectively by Hg2+ ions. Furthermore, this compound also indicated for its superb anti-interference ability among other ions. It is important to mention that this compound could be employed to detect a very low amount of Hg2+ ions, which are highly toxic and general contaminants. The docking study shows that the molecule, 2,3-dihydro-quinazolin-4(1H)-one, is a good inhibitor for the 5ACC enzyme.

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来源期刊

Chemistry-Didactics-Ecology-Metrology MULTIDISCIPLINARY SCIENCES-

CiteScore

1.50

自引率

50.00%

发文量