乳腺癌类器官个体化治疗的进展

Organs-on-a-chip Pub Date : 2023-05-12 DOI:10.1016/j.ooc.2023.100028

Xuelu Li , Dandan Zhu

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引用次数: 0

摘要

乳腺类器官和乳腺癌类器官一直是乳腺和乳腺癌研究的重要工具。在过去的几年里，乳腺癌类器官在很大程度上模仿原始乳腺癌组织的结构和功能特征方面显示出巨大的潜力。本文将介绍乳腺癌类器官的细胞来源和生成策略。综述了目前乳腺癌类器官的研究进展，包括疾病模型、活体生物库、药物筛选和个性化治疗。最后，我们将讨论当前乳腺癌类器官从基础到临床的未来机遇和挑战。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Advances in breast cancer organoid for individualized treatment

Breast organoids and breast cancer organoids have been a crucial tool for mammary gland and breast cancer research. In the last several years, breast cancer organoids have shown tremendous potentials for largely mimicking the structural and functional features of the original breast cancer tissue. In this review, the cell source and strategy for generating breast cancer organoids will be introduced. Then, the current progress of breast cancer organoids will be summarized, including disease model, living biobank, drug screening and personalized therapy. Ultimately, we will discuss the future opportunities and challenges of current breast cancer organoids from basic to clinical.

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来源期刊

Organs-on-a-chip Analytical Chemistry, Biochemistry, Genetics and Molecular Biology (General), Cell Biology, Pharmacology, Toxicology and Pharmaceutics (General)

自引率

0.00%

发文量

审稿时长

125 days