成都市无偿献血者丙氨酸转氨酶影响因素分析

国际输血及血液学杂志 Pub Date : 2019-09-20 DOI:10.3760/CMA.J.ISSN.1673-419X.2019.05.008

Guangxiang Xi, Min-jie Zhou, Lanjiang Zhang, Li Zhong, Shuangli Liu

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The information management system of Tangshan Qiao 5.0 was used to collect the data of blood donors including gender, age, height, weight, marital status, nationality, occupation, educational level and the seasons of blood donation. The ALT unqualified rates of blood donors with different demographic characteristics (gender, age, marital status, nationality, occupation and education level), seasons of blood donation and body mass index (BMI) were calculated respectively. Chi-square test was used to compare the ALT unqualified rates of blood donors with different demographic characteristics, seasons of blood donation and BMI. Multivariate unconditional logistic regression analysis was used to further study the independent influence factors of ALT disqualification in voluntary blood donors. The procedures followed in this study were in accordance with the requirements of the World Medical Association Declaration of Helsinki revised in 2013. And the Informed Consent of Blood Donors were signed with all blood donors before blood donation. \n \n \nResults \n① Among the 16 424 voluntary donors in this study, and the unqualified rate of ALT was 14.4% (2 363/16 424). Among them, a number of 2 256 donors failed in ALT primary screening, accounting for 95.5% (2 256/2 363); and 107 donors failed in ALT laboratory re-examination, accounting for 4.5% (107/2 363). ② The results of univariate analysis for the influence factors of ALT disqualification in 16 424 voluntary blood donors in this study showed that there were significant differences in ALT unqualified rates among donors of different gender, age, marital status, occupation, education level, seasons of blood donation and BMI, respectively (χ2=872.65, 627.76, 575.94, 641.88, 150.64, 50.71, 2 152.05; P<0.001). ③ The results of multivariate unconditional logistic regression analysis showed that male (OR=3.52, 95%CI: 3.13-3.96, P<0.001), age of 26-35 years (OR=1.25, 95%CI: 1.07-1.46, P<0.001), 18.5 kg/m2 ≤ BMI<25.0 kg/m2 (OR=2.34, 95%CI: 1.24-4.45, P=0.010), 25.0 kg/m2≤BMI<28.0 kg/m2 (OR=7.51, 95%CI: 3.98-14.29, P<0.001) and BMI≥28.0 kg/m2 (OR=19.48, 95%CI: 10.13-37.45, P<0.001); married (OR=1.27, 95%CI: 1.09-1.47, P<0.001); blood donation in summer (OR=1.50, 95%CI: 1.26-1.79, P<0.001), blood donation in autumn (OR=1.79, 95%CI: 1.51-2.13, P<0.001), blood donation in winter (OR=1.27, 95%CI: 1.02-1.47, P<0.001) were the independent risk factors for ALT disqualification in blood donors. Student donor was the independent protective factor for ALT disqualification of blood donors (OR=0.31, 95%CI: 0.25-0.37, P<0.001). \n \n \nConclusions \nThe ALT unqualified rate of blood donors in Chengdu is at a high level. Independent risk factors for ALT disqualification in blood donors included age of 26-35 years, BMI≥18.5 kg/m2, married, and blood donation in summer, autumn and winter. In view of these independent risk factors, corresponding measures should be taken to reduce the ALT unqualified rate of voluntary blood donors in Chengdu. \n \n \nKey words: \nBlood donors; Alanine transaminase; Population structure; Influence factors; Unqualified rate","PeriodicalId":13774,"journal":{"name":"国际输血及血液学杂志","volume":"42 1","pages":"413-419"},"PeriodicalIF":0.0000,"publicationDate":"2019-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Analysis of influence factors of alanine transaminase in voluntary blood donors in Chengdu\",\"authors\":\"Guangxiang Xi, Min-jie Zhou, Lanjiang Zhang, Li Zhong, Shuangli Liu\",\"doi\":\"10.3760/CMA.J.ISSN.1673-419X.2019.05.008\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Objective \\nTo explore the influence factors of unqualified alanine aminotransferase (ALT) of voluntary blood donors in Chengdu. \\n \\n \\nMethods \\nFrom June 1, 2012 to June 1, 2013, a total of 16 424 voluntary blood donors from a street blood collection point of Chengdu Blood Center were selected as subjects by random sampling method. 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Among them, a number of 2 256 donors failed in ALT primary screening, accounting for 95.5% (2 256/2 363); and 107 donors failed in ALT laboratory re-examination, accounting for 4.5% (107/2 363). ② The results of univariate analysis for the influence factors of ALT disqualification in 16 424 voluntary blood donors in this study showed that there were significant differences in ALT unqualified rates among donors of different gender, age, marital status, occupation, education level, seasons of blood donation and BMI, respectively (χ2=872.65, 627.76, 575.94, 641.88, 150.64, 50.71, 2 152.05; P<0.001). ③ The results of multivariate unconditional logistic regression analysis showed that male (OR=3.52, 95%CI: 3.13-3.96, P<0.001), age of 26-35 years (OR=1.25, 95%CI: 1.07-1.46, P<0.001), 18.5 kg/m2 ≤ BMI<25.0 kg/m2 (OR=2.34, 95%CI: 1.24-4.45, P=0.010), 25.0 kg/m2≤BMI<28.0 kg/m2 (OR=7.51, 95%CI: 3.98-14.29, P<0.001) and BMI≥28.0 kg/m2 (OR=19.48, 95%CI: 10.13-37.45, P<0.001); married (OR=1.27, 95%CI: 1.09-1.47, P<0.001); blood donation in summer (OR=1.50, 95%CI: 1.26-1.79, P<0.001), blood donation in autumn (OR=1.79, 95%CI: 1.51-2.13, P<0.001), blood donation in winter (OR=1.27, 95%CI: 1.02-1.47, P<0.001) were the independent risk factors for ALT disqualification in blood donors. 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引用次数: 0

摘要

目的探讨成都市无偿献血者丙氨酸氨基转移酶（ALT）不合格的影响因素。方法自2012年6月1日至2013年6月31日，采用随机抽样方法，抽取成都市血液中心某街道采血点自愿献血者16424人作为受试者。其中，男性捐赠者为8 860人，女性捐赠者为7 564人，年龄在18至55岁之间。ALT初筛血样采用干化学法检测，ALT实验室复检血样采用速率法检测。ALT值>40U/L被判定为不符合ALT血液筛查或献血者实验室复检的要求。采用唐山巧5.0信息管理系统采集献血者的性别、年龄、身高、体重、婚姻状况、民族、职业、文化程度、献血季节等信息。分别计算不同人口统计学特征（性别、年龄、婚姻状况、国籍、职业和教育水平）、献血季节和体重指数（BMI）的献血者ALT不合格率。采用卡方检验比较不同人口统计学特征、献血季节和BMI的献血者ALT不合格率。采用多因素无条件logistic回归分析，进一步探讨自愿献血者ALT不合格的独立影响因素。本研究遵循的程序符合2013年修订的《世界医学会赫尔辛基宣言》的要求。并在献血前与所有献血者签订《献血者知情同意书》。结果①在16 424名自愿献血者中，ALT不合格率为14.4%（2 363/16424）。其中2 256例供者ALT初筛失败，占95.5%（2 256/2 363）；供者ALT复查失败107例，占4.5%（107/2363）本研究对16424名自愿献血者ALT不合格影响因素的单因素分析结果表明，不同性别、年龄、婚姻状况、职业、文化程度、献血季节和BMI的献血者ALT的不合格率存在显著差异，③多因素无条件logistic回归分析结果显示，男性（OR=3.52，95%CI:3.13-3.96，P<0.001），年龄26-35岁（OR=1.25，95%CI:1.07-1.46，P=0.001），18.5kg/m2≤BMI<25.0kg/m2（OR=2.34，95%CI:1.24-4.45，P=0.010），25.0 kg/m2≤BMI＜28.0 kg/m2（OR=7.51，95%CI:3.98-14.29，P＜0.001），BMI≥28.0 kg/m 2（OR=19.48，95%CI:10.13-37.45，P＜001）；已婚（OR=1.27，95%CI:1.09-1.47，P<0.001）；夏季献血（OR=1.50，95%CI:1.26-1.79，P<0.001）、秋季献血（OR=1.79，95%CI:1.51-2.13，P<0.001。结论成都市献血员ALT不合格率较高。献血者ALT不合格的独立危险因素包括年龄26-35岁，BMI≥18.5kg/m2，已婚，夏、秋、冬季献血。针对这些独立的危险因素，应采取相应措施，降低成都市自愿献血者ALT不合格率。关键词：献血者；丙氨酸转氨酶；人口结构；影响因素；不合格率

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Analysis of influence factors of alanine transaminase in voluntary blood donors in Chengdu

Objective To explore the influence factors of unqualified alanine aminotransferase (ALT) of voluntary blood donors in Chengdu. Methods From June 1, 2012 to June 1, 2013, a total of 16 424 voluntary blood donors from a street blood collection point of Chengdu Blood Center were selected as subjects by random sampling method. Among them, there were 8 860 male and 7 564 female donors, aged from 18 to 55 years. Blood samples for ALT primary screening were detected by dry chemical method, and blood samples for ALT laboratory re-examination were detected by rate method. The ALT value > 40 U/L was determined to be unqualified for ALT blood screening or laboratory re-examination of blood donors. The information management system of Tangshan Qiao 5.0 was used to collect the data of blood donors including gender, age, height, weight, marital status, nationality, occupation, educational level and the seasons of blood donation. The ALT unqualified rates of blood donors with different demographic characteristics (gender, age, marital status, nationality, occupation and education level), seasons of blood donation and body mass index (BMI) were calculated respectively. Chi-square test was used to compare the ALT unqualified rates of blood donors with different demographic characteristics, seasons of blood donation and BMI. Multivariate unconditional logistic regression analysis was used to further study the independent influence factors of ALT disqualification in voluntary blood donors. The procedures followed in this study were in accordance with the requirements of the World Medical Association Declaration of Helsinki revised in 2013. And the Informed Consent of Blood Donors were signed with all blood donors before blood donation. Results ① Among the 16 424 voluntary donors in this study, and the unqualified rate of ALT was 14.4% (2 363/16 424). Among them, a number of 2 256 donors failed in ALT primary screening, accounting for 95.5% (2 256/2 363); and 107 donors failed in ALT laboratory re-examination, accounting for 4.5% (107/2 363). ② The results of univariate analysis for the influence factors of ALT disqualification in 16 424 voluntary blood donors in this study showed that there were significant differences in ALT unqualified rates among donors of different gender, age, marital status, occupation, education level, seasons of blood donation and BMI, respectively (χ2=872.65, 627.76, 575.94, 641.88, 150.64, 50.71, 2 152.05; P<0.001). ③ The results of multivariate unconditional logistic regression analysis showed that male (OR=3.52, 95%CI: 3.13-3.96, P<0.001), age of 26-35 years (OR=1.25, 95%CI: 1.07-1.46, P<0.001), 18.5 kg/m2 ≤ BMI<25.0 kg/m2 (OR=2.34, 95%CI: 1.24-4.45, P=0.010), 25.0 kg/m2≤BMI<28.0 kg/m2 (OR=7.51, 95%CI: 3.98-14.29, P<0.001) and BMI≥28.0 kg/m2 (OR=19.48, 95%CI: 10.13-37.45, P<0.001); married (OR=1.27, 95%CI: 1.09-1.47, P<0.001); blood donation in summer (OR=1.50, 95%CI: 1.26-1.79, P<0.001), blood donation in autumn (OR=1.79, 95%CI: 1.51-2.13, P<0.001), blood donation in winter (OR=1.27, 95%CI: 1.02-1.47, P<0.001) were the independent risk factors for ALT disqualification in blood donors. Student donor was the independent protective factor for ALT disqualification of blood donors (OR=0.31, 95%CI: 0.25-0.37, P<0.001). Conclusions The ALT unqualified rate of blood donors in Chengdu is at a high level. Independent risk factors for ALT disqualification in blood donors included age of 26-35 years, BMI≥18.5 kg/m2, married, and blood donation in summer, autumn and winter. In view of these independent risk factors, corresponding measures should be taken to reduce the ALT unqualified rate of voluntary blood donors in Chengdu. Key words: Blood donors; Alanine transaminase; Population structure; Influence factors; Unqualified rate

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国际输血及血液学杂志

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期刊介绍： The International Journal of Transfusion and Hematology was founded in September 1978. It is a comprehensive academic journal in the field of transfusion and hematology, supervised by the National Health Commission and co-sponsored by the Chinese Medical Association, West China Second Hospital of Sichuan University, and the Institute of Transfusion Medicine of the Chinese Academy of Medical Sciences. The journal is a comprehensive academic journal that combines the basic and clinical aspects of transfusion and hematology and is publicly distributed at home and abroad. The International Journal of Transfusion and Hematology mainly reports on the basic and clinical scientific research results and progress in the field of transfusion and hematology, new experiences, new methods, and new technologies in clinical diagnosis and treatment, introduces domestic and foreign research trends, conducts academic exchanges, and promotes the development of basic and clinical research in the field of transfusion and hematology.