参与慢性血液透析继发性矿物质骨疾病的生物标志物

I. A. Vacaroiu, F. Calangiu, G. Tănase, Sebastian Isac, D. Georgescu, D. Dragoș, C. Cobilinschi, L. V. Chiperi, D. Ionescu, Andra-Elena Balcangiu-Stroescu, A. Călinoiu, R. Tulin, D. Balan
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摘要

摘要介绍。慢性肾脏疾病(CKD)是老年人最普遍的公共卫生问题之一。终末期肾病(ESRD)最常见的治疗方法是透析。在CKD的状态和可能的结果上,性别之间存在一些明显的差异。本研究旨在揭示这些被忽视的www变化及其含义。材料和方法。我们对CKD患者进行了一项观察性研究,受试者接受血液透析至少2年。对于参与者,我们选择了相同数量的男性和女性,根据性别分为两组。监测以下血浆参数水平:肌酐、尿素、碳酸氢盐、磷、钙、碱性磷酸酶、维生素D、FGF-23和tnf - α。采用TTEST和CORREL检验评估两组间变量的差异。结果。血浆FGF-23水平与性别之间存在显著相关性(p =0.02)。关于血浆尿素水平,除了预期的透析前后水平差异外,我们还发现其透析后值与性别之间存在显著相关性(p =0.045)。血浆碱性磷酸酶水平与性别呈极显著相关(p =0.01)。结论。血浆肌酐、尿素、碱性磷酸酶、维生素D、FGF-23水平与性别有显著相关性。女性的肌酐和尿素水平较低,而男性的血浆维生素D、碱性磷酸酶和FGF-23水平较低。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Biomarkers Involved in the Mineral-Bone Disorders Secondary to Chronic Hemodialysis
Abstract Introduction. Chronic kidney disease (CKD) is one of the most prevalent public health problems of the elderly population. End-Stage Renal Disease (ESRD)’s most common treatment is dialysis. There are some dissimilarities between the sexes that are apparent in the status and the possible outcomes of CKD. This study aims to shed some light on these somewhat overlooked wwwvariations and their implications. Materials and methods. We conducted an observational study on subjects with CKD, undergoing hemodialysis for at least 2 years. For participation, we selected an equal number of men and women, which were divided into 2 groups according to gender. Plasma levels of the following parameters were monitored: creatinine, urea, bicarbonate, phosphorus, calcium, alkaline phosphatase, vitamin D, FGF-23 and TNF-alpha. The differences of the variables between the two groups were evaluated using TTEST and CORREL test. Results. A significant correlation was between the plasma levels of FGF-23 and gender (p =0.02). Regarding the plasmatic levels of urea, besides the expected difference in pre- and post- dialysis levels, we obtained a significant correlation between its post-dialysis value and gender (p =0.045). In regard to the plasmatic levels of the alkaline phosphatase, there was a significant correlation between its value and gender (p =0.01). Conclusions. There is a significant correlation between the plasmatic levels of creatinine, urea, alkaline phosphatase, vitamin D, FGF-23 and gender. Women present lower levels of creatinine and urea, while men present lower plasmatic levels of vitamin D, alkaline phosphatase and FGF-23.
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