蜂王浆对溴氰菊酯所致雄性白化大鼠肝肾毒性的保护作用:生化和组织病理学研究。

Tasbeeh Mostafa, Khalil Atef, Mouchira mohi el din
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引用次数: 0

摘要

竞争利益:作者宣称不存在竞争。摘要溴氰菊酯(DM)是对人类、动物、鱼类和鸟类毒性最大的环境污染物和工业污染物之一。人类和动物接触溴氰菊酯的最常见来源是受污染的水和食物。本研究旨在评价溴氰菊酯的肾肝毒性。使用24只雄性大鼠。第一组作为对照。第二组和第三组分别口服溴氰菊酯,剂量为LD50的1/ 10%,即0.6mg\kg体重,外加蜂王浆(RJ),剂量为100 mg/kg/天,连续两个月。口服dm诱导的生化和组织病理学改变。与对照组相比,DM毒性在肝肾功能测试中表现出变化,表现为AST、ALT、尿素、尿酸和肌酐升高,血浆蛋白未见变化。与DM组相比,给予RJ可使肝肾功能恢复,从而改善肝肾毒性。在病理学上,溴氰菊酯组的肝脏和肾脏出现了严重的退行性和坏死性变化,在有保护性蜂王凝胶物质的情况下,肝脏和肾脏的病变改善为中度至轻度。本研究表明蜂王凝胶物质具有降低溴氰菊酯致伤的副作用和提高其改善率的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Protective Effects of Royal Jelly against Hepatorenal Toxicity Induced by Deltamethrin in Male Albino Rats: Biochemical and Histopathological Studies.
Competing interest: The authors have declared that no competing exists. Abstract Deltamethrin (DM) is one of the most environmental and industrial pollutants that are toxic to humans, animals, fishes, and birds. The most common sources of human and animal exposure to deltamethrin (DM) are polluted water and food . This study was done to evaluate the nephrohepatic toxicity of deltamethrin. Twenty-four male rats were used. The first group was used as a control. The second and third groups were given deltamethrin orally in a dose of 1/10 % of the LD50 equal to 0.6mg\kg bwt alone plus royal jelly (RJ) at a dose of 100 mg/kg/day for two months, respectively. Oral administration of DM-induced biochemical and histopathological alterations. DM toxicity exhibited changes in the liver and kidney function tests manifested by an increase in AST, ALT, urea, uric acid and creatinine with no changes noticed in plasma proteins when compared to the control group. Giving RJ ameliorated the hepatorenal toxicity by causing recovery in both liver and kidney functions in comparison to DM given group. Pathologically, severe degenerative and necrotic changes in livers and kidneys were present in the deltamethrin group, where it improved to moderate to mild lesions with a protective royal gel substance. This study concluded that royal gel substance has been shown to benefit in lower down the side effects and increasing the rate of improvement of injury induced by deltamethrin.
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