{"title":"转化生长因子β和骨髓来源的抑制细胞在癌症中的相互作用","authors":"J. Santibañez, Suncica Bjelica","doi":"10.2174/1876401001706010001","DOIUrl":null,"url":null,"abstract":"Received: May 31, 2017 Revised: August 08, 2017 Accepted: August 18, 2017 Abstract: Background: Transforming growth factor-beta1 (TGF-β1) is a pleiotropic cytokine with a double role in cancer through its capacity to inhibit early stages of tumors while enhancing tumor progression at late stages of tumor progression. Moreover, TGF-β1 is a potent immunosuppressive cytokine within the tumor microenvironment that allows cancer cells to escape from immune surveillance, which largely contributes to the tumor progression.","PeriodicalId":93682,"journal":{"name":"The Open cancer immunology journal","volume":"06 1","pages":"1-14"},"PeriodicalIF":0.0000,"publicationDate":"2017-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"5","resultStr":"{\"title\":\"Transforming Growth Factor-Beta and Myeloid-Derived Suppressor Cells Interplay in Cancer\",\"authors\":\"J. Santibañez, Suncica Bjelica\",\"doi\":\"10.2174/1876401001706010001\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Received: May 31, 2017 Revised: August 08, 2017 Accepted: August 18, 2017 Abstract: Background: Transforming growth factor-beta1 (TGF-β1) is a pleiotropic cytokine with a double role in cancer through its capacity to inhibit early stages of tumors while enhancing tumor progression at late stages of tumor progression. Moreover, TGF-β1 is a potent immunosuppressive cytokine within the tumor microenvironment that allows cancer cells to escape from immune surveillance, which largely contributes to the tumor progression.\",\"PeriodicalId\":93682,\"journal\":{\"name\":\"The Open cancer immunology journal\",\"volume\":\"06 1\",\"pages\":\"1-14\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2017-10-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"5\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The Open cancer immunology journal\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2174/1876401001706010001\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Open cancer immunology journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/1876401001706010001","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Transforming Growth Factor-Beta and Myeloid-Derived Suppressor Cells Interplay in Cancer
Received: May 31, 2017 Revised: August 08, 2017 Accepted: August 18, 2017 Abstract: Background: Transforming growth factor-beta1 (TGF-β1) is a pleiotropic cytokine with a double role in cancer through its capacity to inhibit early stages of tumors while enhancing tumor progression at late stages of tumor progression. Moreover, TGF-β1 is a potent immunosuppressive cytokine within the tumor microenvironment that allows cancer cells to escape from immune surveillance, which largely contributes to the tumor progression.
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