衰老过程中组织再生能力的丧失——肌腱

Sandra Carvalho, Valério Margarida Pimenta Queiroz, Ferro Inês Monteiro, Campos Inês, C. Lina
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引用次数: 0

摘要

衰老过程的本质是失去不同器官和组织的再生能力,变得更容易受到攻击和功能受损。肌腱衰老是一个复杂的过程,然而,其他组织的类似机制提出了López-Otín等人[1]的“衰老的霍尔马克”模型。肌腱结构和细胞组成也是独特的,这使得该领域的科学研究既是一项非常具体和选择性的任务。间充质干细胞(MSC),更具体地说,腱干/祖细胞(TSPC)可能具有关键重要性。肌腱疾病是世界上最常见的疾病之一,目前随着人类预期寿命的延长而增加。这篇综述建议对老化肌腱及其可用治疗靶点潜力的现有技术进行简要总结。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Loss of Tissue Regenerative Capacity in Aging - The Tendon
Intrinsic to the process of aging is the loss of the ability to regenerate of different organs and tissues, becoming more susceptible to aggression and impaired function. Tendon aging is a complicated process following, however, similar mechanisms of other tissues proposed model of the “Hallmarks of Aging”, by López-Otín, et al [1]. Tendon structure and cellular composition is also unique, which makes scientific research in this field both a very specific and select task. Mesenchymal Stem Cells (MSCs), more specifically, Tendon stem/progenitor cells (TSPCs) may be of key importance. Tendon disease is one of the most common entities worldwide, and is currently increasing with the augment of the human life-expectancy. This review proposes to make a short summary of the state of the art in both the aging tendon and its available treatment target potentials.
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