Long pentraxin 3作为新冠肺炎严重程度的标志物:证据和前景

IF 3.8 3区 医学 Q1 MEDICAL LABORATORY TECHNOLOGY
R. Assandri, Silvia Accordino, Ciro Canetta, E. Buscarini, A. Scartabellati, Chiara Tolassi, F. Serana
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引用次数: 8

摘要

几种实验室检测在2019冠状病毒病(COVID-19)中具有特征性改变,但在预测疾病结局方面并不完全准确。长戊烷素3 (PTX3)被许多免疫细胞类型迅速直接释放到炎症部位。先前的研究表明,PTX3与各种炎症条件下的疾病严重程度相关。我们的研究调查了PTX3作为COVID-19严重程度的潜在标记物的使用,并将其在检测更严重的疾病形式与常规实验室参数的性能进行了比较。材料与方法回顾性分析住院时获得的RT-PCR确诊COVID-19患者的血清样本。重症监护病房(ICU)被认为是重症COVID-19的替代终点。戊traxin 3采用商业酶联免疫吸附法测定。结果2020年5月1日至2020年6月30日共招募96例患者;75/96转ICU。ICU组戊氧欣3高于非ICU组(35.86 ng/mL vs 10.61 ng/mL, P < 0.001)。单因素和多因素logistic回归模型显示,在控制合并症后,PTX3是唯一显著的实验室预测因子(OR: 1.68 (1.19-2.29), P = 0.003)。Receiver Operator Characteristic curve分析显示,PTX3与c反应蛋白(CRP)、乳酸脱氢酶(LD)、铁蛋白(铁蛋白)鉴别ICU患者的准确率较高(AUC = 0.98;CRP = 0.66;Ld = 0.70;铁蛋白= 0.67,P < 0.001)。PTX3 > 18 ng/mL的临界值在识别需要ICU的患者时灵敏度为96%,特异性为100%。结论PTX3值高预示COVID-19病情加重。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Long pentraxin 3 as a marker of COVID-19 severity: evidences and perspectives
Introduction Several laboratory tests are characteristically altered in Coronavirus Disease 2019 (COVID-19), but are not totally accurate in predicting the disease outcome. The long pentraxin 3 (PTX3) is quickly released directly at inflammation sites by many immune cell types. Previous studies have shown that PTX3 correlated with disease severity in various inflammatory conditions. Our study investigated the use of PTX3 as a potential marker of COVID-19 severity and compared its performance in detecting a more severe form of the disease with that of routine laboratory parameters. Materials and methods Stored serum samples of RT-PCR confirmed COVID-19 cases that had been obtained at hospital admission were retrospectively analysed. Intensive care unit (ICU) stay was considered a surrogate endpoint of severe COVID-19. Pentraxin 3 was measured by a commercial enzyme-linked immunosorbent assay. Results A total of 96 patients were recruited from May 1st, 2020 to June 30th, 2020; 75/96 were transferred to ICU. Pentraxin 3 was higher in ICU vs non-ICU patients (35.86 vs 10.61 ng/mL, P < 0.001). Univariate and multivariate logistic regression models demonstrated that the only significant laboratory predictor of ICU stay was PTX3 (OR: 1.68 (1.19-2.29), P = 0.003), after controlling for comorbidities. The Receiver Operator Characteristic curve analysis showed that PTX3 had a higher accuracy compared to C-reactive protein (CRP), lactate dehydrogenase (LD), ferritin in identifying ICU patients (AUC of PTX3 = 0.98; CRP = 0.66; LD = 0.70; ferritin = 0.67, P < 0.001). A cut-off of PTX3 > 18 ng/mL yielded a sensitivity of 96% and a specificity of 100% in identifying patients requiring ICU. Conclusion High values of PTX3 predict a more severe COVID-19.
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来源期刊
Biochemia Medica
Biochemia Medica 医学-医学实验技术
CiteScore
5.50
自引率
3.00%
发文量
70
审稿时长
>12 weeks
期刊介绍: Biochemia Medica is the official peer-reviewed journal of the Croatian Society of Medical Biochemistry and Laboratory Medicine. Journal provides a wide coverage of research in all aspects of clinical chemistry and laboratory medicine. Following categories fit into the scope of the Journal: general clinical chemistry, haematology and haemostasis, molecular diagnostics and endocrinology. Development, validation and verification of analytical techniques and methods applicable to clinical chemistry and laboratory medicine are welcome as well as studies dealing with laboratory organization, automation and quality control. Journal publishes on a regular basis educative preanalytical case reports (Preanalytical mysteries), articles dealing with applied biostatistics (Lessons in biostatistics) and research integrity (Research integrity corner).
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