Gede W.K. Duarsa , Yeremia G. Kusumah , Ronald Sugianto , Pande M.W. Tirtayasa , Tjokorda G.B. Mahadewa
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The sample was BPH patients with several history qualifications.</p></div><div><h3>Results</h3><p>Our sample was 83 respondents, ranging from 50 years to 80 years, 61 respondents with ED and 22 with non-ED. The International Prostate Symptom Score showed a significant result, which indicates that ED is more common in patients with higher International Prostate Symptom Score (<em>p</em>=0.002). Moreover, the TNF-α of ≥43.9 pg/mg and TGF-β of ≥175.8 pg/mL were significantly associated with the presence of ED in BPH patients (<em>p</em><0.0001). 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The sample was BPH patients with several history qualifications.</p></div><div><h3>Results</h3><p>Our sample was 83 respondents, ranging from 50 years to 80 years, 61 respondents with ED and 22 with non-ED. The International Prostate Symptom Score showed a significant result, which indicates that ED is more common in patients with higher International Prostate Symptom Score (<em>p</em>=0.002). Moreover, the TNF-α of ≥43.9 pg/mg and TGF-β of ≥175.8 pg/mL were significantly associated with the presence of ED in BPH patients (<em>p</em><0.0001). 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引用次数: 0
摘要
目的勃起功能障碍（ED）是指阴茎持续或反复勃起不足，无法进行性活动。肿瘤坏死因子-α（TNF-α）可诱导转化生长因子-β（TGF-β），使上皮细胞转化为间质细胞，从而影响 ED。本研究旨在评估 TNF-α、TGF-β、下尿路症状程度和前列腺体积对良性前列腺增生症（BPH）患者出现 ED 的作用。样本为具有多种病史资格的良性前列腺增生症患者。结果我们的样本有 83 名受访者，年龄从 50 岁到 80 岁不等，其中 61 名受访者患有前列腺增生症，22 名受访者没有前列腺增生症。国际前列腺症状评分结果显示，ED在国际前列腺症状评分较高的患者中更为常见（P=0.002）。此外，TNF-α≥43.9 pg/mg和TGF-β≥175.8 pg/mL与良性前列腺增生症患者出现ED显著相关（p<0.0001）。结论TNF-α、TGF-β和下尿路症状严重程度可预测良性前列腺增生症患者发生 ED 的情况，而前列腺体积与 ED 的关系不大。
Tumor necrosis factor-alpha, transforming growth factor-beta, degree of lower urinary tract symptoms as predictors of erectile dysfunction in benign prostatic hyperplasia patients
Objective
Erectile dysfunction (ED) is a condition of insufficient penile erection, consistently or recurrently, for sexual activity. Tumor necrosis factor-alpha (TNF-α) induces transforming growth factor-beta (TGF-β), which causes the transition of epithelial cells into mesenchymal cells that affect ED. This study aimed to evaluate the roles of TNF-α, TGF-β, degree of lower urinary tract symptoms, and prostatic volume for the presence of ED in benign prostatic hyperplasia (BPH) patients.
Methods
Our study performed an analytic observational retrospective cohort study using secondary data from four hospitals in Bali, Indonesia, including medical records and other administrative data. The sample was BPH patients with several history qualifications.
Results
Our sample was 83 respondents, ranging from 50 years to 80 years, 61 respondents with ED and 22 with non-ED. The International Prostate Symptom Score showed a significant result, which indicates that ED is more common in patients with higher International Prostate Symptom Score (p=0.002). Moreover, the TNF-α of ≥43.9 pg/mg and TGF-β of ≥175.8 pg/mL were significantly associated with the presence of ED in BPH patients (p<0.0001). Despite these results, prostate volume is not significant with ED (p=0.947).
Conclusion
TNF-α, TGF-β, and lower urinary tract symptoms severity can predict the occurrence of ED in BPH, while prostatic volume was not significant.
期刊介绍：
Asian Journal of Urology (AJUR), launched in October 2014, is an international peer-reviewed Open Access journal jointly founded by Shanghai Association for Science and Technology (SAST) and Second Military Medical University (SMMU). AJUR aims to build a communication platform for international researchers to effectively share scholarly achievements. It focuses on all specialties of urology both scientifically and clinically, with article types widely covering editorials, opinions, perspectives, reviews and mini-reviews, original articles, cases reports, rapid communications, and letters, etc. Fields of particular interest to the journal including, but not limited to: • Surgical oncology • Endourology • Calculi • Female urology • Erectile dysfunction • Infertility • Pediatric urology • Renal transplantation • Reconstructive surgery • Radiology • Pathology • Neurourology.
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